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\ p None B a = c @ = Z ?N*8 X" 1 Arial1 Arial1 Arial1 Arial1 Arial1 Arial1 Arial General ` Table_2 d G Cell DNA damagingg IC50 of DNA damaging agents (µM) in the absence or presence of panobinostat (nM) P line
agents 0 5 10 20 40 Value Etoposide 2.200.20 ND 1.310.22 (0.74) 1.000.22 (0.74) 0.600.12 (0.84) <0.05 SK-N-SH Doxorubicin 0.430.03 0.270.04 (0.77) 0.160.01 (0.65) 0.080.01 (0.76) Cisplatin 3.080.14 1.560.14 (0.65) 1.110.19 (0.66) 0.600.27 (0.78) <0.005 Etoposide
21.532.42 13.890.44 (0.78) 8.630.30 (0.67) 3.000.35 (0.67) SK-N-BE(2) 2.210.03 1.150.13 (0.65) 0.550.03 (0.51) 0.200.02 (0.62)
26.391.28 14.671.43 (0.69) 7.021.08 (0.53) 1.840.30 (0.60)
36.162.89 14.020.68 (0.57) 9.232.13 (0.62) 7.291.88 (0.93) SK-N-AS 0.890.08 0.450.01 (0.69) 0.300.01 (0.70) 0.250.01 (1.01)
12.200.68 7.890.60 (0.83) 5.630.49 (0.83) 3.100.87 (0.98)
27.433.33 8.501.54 (0.54) 5.270.78 (0.65) 1.870.53 (0.99) SK-N-DZ 1.380.15 0.910.11 (0.89) 0.540.08 (0.85) 0.150.03 (1.03)
26.091.67 9.401.90 (0.59) 4.95 1.53 (0.65) 0.870.39 (0.95)
d MbP?_ % * + &P &F