Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_DIRECT GO:0030054~cell junction 21 8.71369294605809 9.972698392397151E-7 SLC8A3, CPLX3, GABRE, DLGAP1, SEPT3, GABRB3, GABRB2, DLGAP2, RIMBP2, NLGN1, GRIN2A, GRIA3, GSG1L, RIMS1, PCLO, GABRR3, HMCN1, XIRP1, LRRTM4, SCIN, LRFN2 224 459 18224 3.7222222222222223 2.3133995486190884E-4 2.3133995486190884E-4 0.0012803012186535234 GOTERM_MF_DIRECT GO:0000989~transcription factor activity, transcription factor binding 5 2.0746887966804977 1.921838274973775E-5 PER2, TP63, FOXO1, LDB2, HMGA2 206 14 16881 29.266643550624135 0.008477685394046586 0.008477685394046586 0.027200540643113058 GOTERM_CC_DIRECT GO:0045211~postsynaptic membrane 12 4.979253112033195 6.007724773530089E-5 GABRR3, GABRE, DLGAP1, CLSTN2, GABRB3, LRRTM4, DLGAP2, GABRB2, NLGN1, GRIN2A, GRIA3, LRFN2 224 211 18224 4.626946513202437 0.013841651252986975 0.0069449417343401265 0.0771005784886869 GOTERM_CC_DIRECT GO:0072562~blood microparticle 10 4.149377593360995 1.0812859623896707E-4 GC, KNG1, FGG, FGB, ALB, C3, CFH, CIB2, AHSG, ZBTB38 224 152 18224 5.352443609022556 0.024775122192370103 0.008327529310075521 0.13872817236320056 KEGG_PATHWAY hsa05033:Nicotine addiction 6 2.4896265560165975 2.2995299379004522E-4 GABRR3, GABRE, GABRB3, GABRB2, GRIN2A, GRIA3 99 40 6910 10.46969696969697 0.04033049481837492 0.04033049481837492 0.2826131165395207 GOTERM_BP_DIRECT GO:0002576~platelet degranulation 8 3.319502074688797 3.1089018968630326E-4 KNG1, FGG, FGB, ALB, APOH, IGF1, ITIH3, AHSG 211 103 16792 6.181199098145678 0.3664762287556055 0.3664762287556055 0.5139627268779035 GOTERM_CC_DIRECT GO:0009986~cell surface 18 7.468879668049793 3.827229384683335E-4 EGFR, TRPC4, CLSTN2, GRIN2A, NLGN1, PTPRT, FGG, KCNQ3, SRPX, CCR6, FGB, APOH, CNTNAP2, UNC5D, ANTXR1, LRFN2, KCNH5, CD28 224 542 18224 2.701897733263047 0.08497941562551836 0.02195752492550651 0.49023345033620824 GOTERM_CC_DIRECT GO:0045202~synapse 10 4.149377593360995 3.9925676702313155E-4 EGFR, GABRE, SEPT3, DLGAP1, GABRB3, GABRB2, RIMBP2, NLGN1, PCDH15, PCLO 224 181 18224 4.494869771112866 0.08848394023233352 0.01835860270661982 0.5113617672951043 KEGG_PATHWAY hsa04080:Neuroactive ligand-receptor interaction 13 5.394190871369295 5.051876140191227E-4 AGTR1, GABRR3, CGA, GABRE, AGTR2, GABRB3, GABRB2, NPY2R, ADRA1B, GRIN2A, GRIA3, HTR1D, VIPR2 99 277 6910 3.2757174634430952 0.08648129967905405 0.04421827788927346 0.6199126837119096 GOTERM_CC_DIRECT GO:0031093~platelet alpha granule lumen 6 2.4896265560165975 5.547507098353057E-4 KNG1, FGG, FGB, ALB, IGF1, AHSG 224 55 18224 8.875324675324674 0.12079560469747719 0.021227763629870555 0.7098627198037666 GOTERM_BP_DIRECT GO:0051592~response to calcium ion 6 2.4896265560165975 7.802001812173686E-4 KCNMA1, EGFR, FGG, FGB, CYTB, PCDH15 211 58 16792 8.232717764340578 0.6820244841666918 0.436106822320656 1.2851250526851987 GOTERM_CC_DIRECT GO:0005886~plasma membrane 72 29.87551867219917 9.018558734112721E-4 SLC8A3, KCNJ16, PLXNA4, GABRB3, SLC15A2, GABRB2, KCNK18, DPP10, RRAD, VIPR2, LGR5, ACVR1C, AGTR1, AGTR2, APOB, KCNQ3, PRMT8, ANO3, GUCY1A2, UNC5D, PAK1, HTR1D, JPH1, KNG1, KCNMA1, EGFR, RET, IRS2, RIMBP2, GRIN2A, CDHR5, PTPRT, KCNA10, GABRR3, CCR6, SLC26A8, ANOS1, WASL, STEAP1, GRB14, KCNH5, CPLX3, C3, ENPP2, NPY2R, GSG1L, RIMS1, CDH6, FGG, AMER2, KCNS2, SORBS1, FGB, ENTPD3, LRFN2, CD28, GABRE, TRPC4, NLGN1, IGF1, GRIA3, PCDH15, MAPK10, SEMA6D, CCDC70, CDH18, ADRA1B, RGS6, RGS7, KIAA0319, ANTXR1, SMPD3 224 4121 18224 1.421430304711062 0.18886839843797032 0.02946087872943004 1.1516545164512282 GOTERM_CC_DIRECT GO:1902711~GABA-A receptor complex 4 1.6597510373443984 0.0012878307654051108 GABRR3, GABRE, GABRB3, GABRB2 224 18 18224 18.079365079365076 0.2584178168112926 0.03668147750121331 1.6407903783189792 GOTERM_BP_DIRECT GO:0007165~signal transduction 28 11.618257261410788 0.001340585699111086 ZNF536, CGA, GABRB3, C3, FST, RASSF9, RRAD, GDNF, VIPR2, FGG, FGB, GUCY1A2, UNC5D, IL1RAPL2, CREBL2, EGFR, ZNF831, GABRE, IRS2, RET, IGF1, PTPRT, MAPK10, HMGA2, TNFSF10, CCR6, ANTXR1, GRB14 211 1161 16792 1.919312898261427 0.8604455050507984 0.48130195658994623 2.1985832154524876 GOTERM_MF_DIRECT GO:0004890~GABA-A receptor activity 4 1.6597510373443984 0.0014814864501697376 GABRR3, GABRE, GABRB3, GABRB2 206 19 16881 17.251916198262645 0.4814843801911699 0.2799197129424872 2.076758704793946 GOTERM_BP_DIRECT GO:0030335~positive regulation of cell migration 9 3.7344398340248963 0.002238708738035333 EGFR, CGA, IRS2, RET, SEMA6D, IGF1, WNT11, PAK1, SNAI2 211 184 16792 3.8926437255306 0.9627501961719382 0.5606799771864661 3.646023833935097 KEGG_PATHWAY hsa04068:FoxO signaling pathway 8 3.319502074688797 0.0028166356377958414 EGFR, IRS2, TNFSF10, RAG1, FOXO1, IGF1, RAG2, MAPK10 99 134 6910 4.167043570028645 0.3964275269955436 0.15489667918175454 3.4114989867547685 KEGG_PATHWAY hsa04723:Retrograde endocannabinoid signaling 7 2.904564315352697 0.0029898434354817087 GABRR3, GABRE, GABRB3, GABRB2, GRIA3, MAPK10, RIMS1 99 101 6910 4.837483748374837 0.41490650756195924 0.12540635577662917 3.61775620958088 GOTERM_MF_DIRECT GO:0008013~beta-catenin binding 6 2.4896265560165975 0.0032203402700632 TRPC4, AMER2, FOXO1, CDHR5, PTPRT, RORA 206 82 16881 5.99609282500592 0.7604307522306377 0.3789255123873658 4.46314282771273 GOTERM_BP_DIRECT GO:0006813~potassium ion transport 6 2.4896265560165975 0.0036499731518676464 KCNJ16, KCNA10, KCNMA1, KCNS2, KCNQ3, KCNK18 211 82 16792 5.823141833314067 0.9953363786446499 0.6582215652765726 5.8798566649503226 GOTERM_MF_DIRECT GO:0043565~sequence-specific DNA binding 15 6.224066390041494 0.004439736167887861 EGR1, ZNF831, TBX3, RAG1, FOXO1, TP63, RORA, NR4A3, SNAI2, PPARGC1A, FOXN4, ZFHX4, ATF3, CSRNP3, CREBL2 206 518 16881 2.372971098699254 0.8607079027608643 0.3890838314701721 6.10426449909649 GOTERM_BP_DIRECT GO:0006928~movement of cell or subcellular component 6 2.4896265560165975 0.004475872087254302 CCR6, ENPP2, ANOS1, IGF1, CHST4, WASL 211 86 16792 5.552298027113412 0.9986195265891613 0.6663139832920824 7.164469896764992 GOTERM_CC_DIRECT GO:0008076~voltage-gated potassium channel complex 6 2.4896265560165975 0.0045141332843114165 KCNJ16, KCNA10, KCNMA1, KCNS2, KCNQ3, CNTNAP2 224 88 18224 5.547077922077921 0.6499396945510367 0.11008360581299548 5.642956559785173 GOTERM_MF_DIRECT GO:0005070~SH3/SH2 adaptor activity 5 2.0746887966804977 0.004738447638414133 SORBS1, SH3BGR, GRB14, TOB1, CD28 206 56 16881 7.316660887656034 0.8780472232061988 0.34349454557131953 6.502269838532193 GOTERM_BP_DIRECT GO:0021983~pituitary gland development 4 1.6597510373443984 0.0050163616997177364 NOG, HMGA2, TBX19, ADCYAP1 211 28 16792 11.368991198375086 0.9993779880598297 0.6516857471590777 7.996215372001025 GOTERM_BP_DIRECT GO:0031639~plasminogen activation 3 1.2448132780082988 0.005288752574429845 FGG, FGB, APOH 211 9 16792 26.527646129541864 0.9995838613661031 0.6220757545586864 8.412732037092264 GOTERM_BP_DIRECT GO:0045893~positive regulation of transcription, DNA-templated 15 6.224066390041494 0.0054535241782301905 EGR1, RET, TBX3, IGF1, FOXO1, TP63, RORA, HMGA2, PPARGC1A, FOXN4, AGTR2, NPAS2, WNT11, KAT6B, CREBL2 211 515 16792 2.317949661804629 0.9996736966297435 0.5901503035969742 8.663825815417747 GOTERM_BP_DIRECT GO:0046326~positive regulation of glucose import 4 1.6597510373443984 0.006104134534992328 IRS2, SORBS1, IGF1, CREBL2 211 30 16792 10.611058451816746 0.9998751416272785 0.5929556160960188 9.648978608846349 GOTERM_MF_DIRECT GO:0001223~transcription coactivator binding 3 1.2448132780082988 0.006193727434926652 FOXO1, RORA, NR4A3 206 10 16881 24.583980582524273 0.9362224316906921 0.3679113489723017 8.418967628881491 GOTERM_BP_DIRECT GO:1902476~chloride transmembrane transport 6 2.4896265560165975 0.006228063287442437 GABRR3, GABRE, SLC26A8, GABRB3, GABRB2, ANO3 211 93 16792 5.134383121846812 0.9998960277615468 0.5655882322771659 9.835495524185777 GOTERM_BP_DIRECT GO:0050679~positive regulation of epithelial cell proliferation 5 2.0746887966804977 0.006711911759672307 EGFR, STOX1, NOG, IGF1, NR4A3 211 60 16792 6.631911532385465 0.9999491332808101 0.5612644655242144 10.56024550460204 GOTERM_BP_DIRECT GO:0007204~positive regulation of cytosolic calcium ion concentration 7 2.904564315352697 0.006803127174728076 KNG1, AGTR1, CCR6, NPY2R, ADRA1B, CIB2, ADCYAP1 211 134 16792 4.157317677017755 0.9999555487262785 0.5373827077549722 10.696261084561954 GOTERM_BP_DIRECT GO:0045907~positive regulation of vasoconstriction 4 1.6597510373443984 0.0073222200258314845 EGFR, FGG, FGB, ADRA1B 211 32 16792 9.9478672985782 0.9999793658998308 0.5372701264548382 11.46661179077315 GOTERM_MF_DIRECT GO:0005230~extracellular ligand-gated ion channel activity 4 1.6597510373443984 0.007364339158806195 GABRR3, GABRE, GABRB3, GABRB2 206 33 16881 9.932921447484555 0.9621632440996304 0.37360996239708766 9.934169404152371 GOTERM_BP_DIRECT GO:0001837~epithelial to mesenchymal transition 4 1.6597510373443984 0.008674125210488558 NOG, WNT11, HMGA2, SNAI2 211 34 16792 9.362698633955953 0.9999972091483312 0.5736995572994233 13.443679471108682 GOTERM_BP_DIRECT GO:0030195~negative regulation of blood coagulation 3 1.2448132780082988 0.009459686039377573 KNG1, APOH, TSPAN8 211 12 16792 19.895734597156398 0.9999991283856458 0.5819095251310569 14.573371854831741 GOTERM_BP_DIRECT GO:0007268~chemical synaptic transmission 9 3.7344398340248963 0.010815995879373668 GABRR3, DLGAP1, KCNQ3, GABRB2, NPY2R, GRIN2A, GRIA3, HTR1D, LRFN2 211 240 16792 2.9843601895734597 0.9999998833833448 0.6090129375024779 16.49129691092115 GOTERM_BP_DIRECT GO:0045944~positive regulation of transcription from RNA polymerase II promoter 22 9.12863070539419 0.011415539451035309 EGR1, EGFR, CGA, NOG, MAFB, IGF1, LDB2, FOXO1, TP63, RORA, NR4A3, HMGA2, GDNF, PPARGC1A, ZBTB38, ADCYAP1, NPAS2, ATF3, CSRNP3, KAT6B, TBX19, CD28 211 981 16792 1.7847346019875259 0.9999999521118146 0.6079458808624745 17.326135795607854 GOTERM_MF_DIRECT GO:0001078~transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding 6 2.4896265560165975 0.01142267088857777 ZNF536, ATF3, TBX3, FOXO1, HMGA2, SNAI2 206 111 16881 4.429546050905274 0.9938380742918064 0.4706845663383117 15.00864122701645 GOTERM_CC_DIRECT GO:0031091~platelet alpha granule 3 1.2448132780082988 0.012312793905371114 FGG, FGB, THBS2 224 14 18224 17.433673469387752 0.943544358570797 0.2498109260802177 14.705018914488344 GOTERM_BP_DIRECT GO:0034765~regulation of ion transmembrane transport 6 2.4896265560165975 0.012839466525095667 KCNJ16, KCNA10, KCNMA1, KCNQ3, KCNE4, KCNH5 211 111 16792 4.301780453439221 0.9999999942287894 0.6315466836549622 19.277570510413867 GOTERM_MF_DIRECT GO:0008201~heparin binding 7 2.904564315352697 0.013517953573271176 KNG1, APOB, CFH, APOH, ANOS1, THBS2, ABI3BP 206 160 16881 3.585163834951456 0.9975928161847392 0.4882514935217319 17.52329148952064 GOTERM_MF_DIRECT GO:0005509~calcium ion binding 17 7.053941908713693 0.01423664473131916 GUCA1B, RET, CLSTN2, ENPP2, PCDH15, CDHR5, PCLO, CDH6, HMCN1, CRB1, CDH18, SCIN, RHBDL3, CIB2, TLL2, THBS2, PKDREJ 206 717 16881 1.942945931673234 0.9982570189539093 0.47017887991603957 18.36977798914331 GOTERM_BP_DIRECT GO:0007156~homophilic cell adhesion via plasma membrane adhesion molecules 7 2.904564315352697 0.01457124405226842 RET, CLSTN2, CDH18, PCDH15, CDHR5, PTPRT, CDH6 211 158 16792 3.5258263843061974 0.9999999995616312 0.6595197068606915 21.592576418082842 GOTERM_BP_DIRECT GO:0048485~sympathetic nervous system development 3 1.2448132780082988 0.014683754593619707 PLXNA4, TP63, GDNF 211 15 16792 15.916587677725117 0.9999999996292814 0.6444449321451611 21.740799104491504 GOTERM_BP_DIRECT GO:0045725~positive regulation of glycogen biosynthetic process 3 1.2448132780082988 0.014683754593619707 IRS2, SORBS1, IGF1 211 15 16792 15.916587677725117 0.9999999996292814 0.6444449321451611 21.740799104491504 GOTERM_BP_DIRECT GO:0007267~cell-cell signaling 9 3.7344398340248963 0.01470749160636946 GUCA1B, CGA, TNFSF10, CRB1, ADRA1B, CHST4, SRD5A2, VIPR2, ADCYAP1 211 254 16792 2.819867895659962 0.999999999642163 0.6279322261548134 21.77203686651937 KEGG_PATHWAY hsa04610:Complement and coagulation cascades 5 2.0746887966804977 0.01628545374589302 KNG1, FGG, FGB, C3, CFH 99 69 6910 5.0578246230420145 0.9470863506770137 0.4444622916756077 18.29532629108507 GOTERM_CC_DIRECT GO:0016021~integral component of membrane 79 32.780082987551864 0.01748950323921717 SLC8A3, KCNJ16, PLXNA4, CLSTN2, GABRB3, SLC15A2, GABRB2, DPP10, MEGF11, VIPR2, LGR5, GLT8D2, AGTR1, TMEM108, ANO3, CNTNAP2, PELI2, UNC5D, SRD5A2, JPH1, EGFR, KCNMA1, ND1, RET, ND4, CNTNAP5, ND5, PLD5, ND2, GRIN2A, CDHR5, PTPRT, CHST4, PCLO, TMEM132D, KCNA10, SLITRK4, SLC26A8, SMPX, GALNT9, STEAP1, PKDREJ, PIANP, KCNH5, FUT9, ENPP2, CYTB, RAG2, GSG1L, GRAMD4, FAM19A5, CDH6, TMEM178B, KCNS2, CRB1, LRRTM4, SYBU, ABCD2, ENTPD3, IL1RAPL2, KCNE4, LRFN2, GABRE, TRPC4, ST6GAL2, KIAA1644, GRIA3, PCDH15, RCAN2, B3GAT1, FAM180B, TNFSF10, SEMA6D, CDH18, KIAA0319, ANTXR1, RHBDL3, GREB1L, SMPD3 224 5163 18224 1.2448604078470438 0.9833186902707262 0.3107376462944872 20.26960741332251 GOTERM_BP_DIRECT GO:0006094~gluconeogenesis 4 1.6597510373443984 0.017529496874315972 ATF3, ALDOB, PER2, PPARGC1A 211 44 16792 7.234812580784146 0.9999999999946905 0.6765664721320838 25.403421176664033 GOTERM_BP_DIRECT GO:0010951~negative regulation of endopeptidase activity 6 2.4896265560165975 0.01803638889963794 KNG1, C3, ANOS1, ITIH3, TFPI2, AHSG 211 121 16792 3.946261407700442 0.9999999999975109 0.671525531312759 26.038674084577384 GOTERM_BP_DIRECT GO:0071805~potassium ion transmembrane transport 6 2.4896265560165975 0.01803638889963794 KCNA10, KCNMA1, KCNS2, KCNQ3, KCNE4, KCNH5 211 121 16792 3.946261407700442 0.9999999999975109 0.671525531312759 26.038674084577384 GOTERM_BP_DIRECT GO:0003151~outflow tract morphogenesis 4 1.6597510373443984 0.019731306559814872 NOG, TBX3, NPY2R, WNT11 211 46 16792 6.9202555120544 0.9999999999998029 0.6896968351040316 28.126078868091863 GOTERM_MF_DIRECT GO:0008137~NADH dehydrogenase (ubiquinone) activity 4 1.6597510373443984 0.020451982499358715 ND1, ND4, ND5, ND2 206 48 16881 6.82888349514563 0.9998942212606163 0.5649074254294868 25.360704057349935 GOTERM_BP_DIRECT GO:0060384~innervation 3 1.2448132780082988 0.020877930944495908 RET, GABRB3, GABRB2 211 18 16792 13.263823064770932 0.9999999999999647 0.6961677554419599 29.50669240047359 GOTERM_CC_DIRECT GO:0034707~chloride channel complex 4 1.6597510373443984 0.022041882290612432 GABRR3, GABRE, GABRB3, GABRB2 224 49 18224 6.641399416909621 0.9943206401543038 0.3500824235873293 24.884405122856755 GOTERM_CC_DIRECT GO:0005747~mitochondrial respiratory chain complex I 4 1.6597510373443984 0.022041882290612432 ND1, ND4, ND5, ND2 224 49 18224 6.641399416909621 0.9943206401543038 0.3500824235873293 24.884405122856755 GOTERM_CC_DIRECT GO:0043034~costamere 3 1.2448132780082988 0.022229407699067023 PGM5, SMPX, SYNM 224 19 18224 12.845864661654135 0.9945677805042207 0.3304739405736028 25.069110336040723 GOTERM_BP_DIRECT GO:0051968~positive regulation of synaptic transmission, glutamatergic 3 1.2448132780082988 0.02314456073608204 EGFR, NLGN1, ADCYAP1 211 19 16792 12.565727113993514 0.9999999999999988 0.7200570124117095 32.16286837949083 GOTERM_BP_DIRECT GO:0090190~positive regulation of branching involved in ureteric bud morphogenesis 3 1.2448132780082988 0.02314456073608204 NOG, AGTR2, GDNF 211 19 16792 12.565727113993514 0.9999999999999988 0.7200570124117095 32.16286837949083 GOTERM_BP_DIRECT GO:0006120~mitochondrial electron transport, NADH to ubiquinone 4 1.6597510373443984 0.02330708738923507 ND1, ND4, ND5, ND2 211 49 16792 6.496566399071478 0.9999999999999991 0.7095786948971594 32.34966749259019 GOTERM_CC_DIRECT GO:0005887~integral component of plasma membrane 27 11.20331950207469 0.0244386892976564 SLC8A3, KCNJ16, PLXNA4, GABRB3, ENPP2, SLC15A2, GABRB2, NPY2R, KCNK18, TSPAN8, VIPR2, LGR5, AGTR1, AGTR2, HTR1D, CD28, TRPC4, RET, GRIN2A, NLGN1, TNFSF10, CCR6, SLC26A8, SEMA6D, ADRA1B, STEAP1, KCNH5 224 1415 18224 1.5523977788995458 0.996785896219296 0.3363595491555398 27.21386336747804 GOTERM_CC_DIRECT GO:0070469~respiratory chain 3 1.2448132780082988 0.024503005664257435 ND5, ND2, CYTB 224 20 18224 12.203571428571427 0.9968346840991797 0.31866431255515393 27.27544457098897 GOTERM_BP_DIRECT GO:0021784~postganglionic parasympathetic fiber development 2 0.8298755186721992 0.0248562470044098 PLXNA4, GDNF 211 2 16792 79.5829383886256 0.9999999999999999 0.7203291739186004 34.10608784406762 GOTERM_BP_DIRECT GO:0046884~follicle-stimulating hormone secretion 2 0.8298755186721992 0.0248562470044098 CGA, TBX3 211 2 16792 79.5829383886256 0.9999999999999999 0.7203291739186004 34.10608784406762 GOTERM_BP_DIRECT GO:0021761~limbic system development 2 0.8298755186721992 0.0248562470044098 TBX3, CNTNAP2 211 2 16792 79.5829383886256 0.9999999999999999 0.7203291739186004 34.10608784406762 GOTERM_CC_DIRECT GO:0014069~postsynaptic density 7 2.904564315352697 0.02590474749425245 DLGAP1, CLSTN2, DLGAP2, ND2, NLGN1, GRIN2A, PCLO 224 184 18224 3.095108695652174 0.9977325850983371 0.31652806312971515 28.605699354272062 GOTERM_BP_DIRECT GO:0045333~cellular respiration 3 1.2448132780082988 0.02796384494248067 ND1, NR4A3, PPARGC1A 211 21 16792 11.368991198375083 1.0 0.7503913119956489 37.50104506564887 GOTERM_BP_DIRECT GO:0007155~cell adhesion 12 4.979253112033195 0.02994061197165674 PGM5, SRPX, SORBS1, CNTNAP5, NLGN1, CNTNAP2, ANOS1, CDHR5, CHST4, PTPRT, THBS2, CDH6 211 459 16792 2.080599696434656 1.0 0.7629517701881254 39.57432672785758 GOTERM_BP_DIRECT GO:0016079~synaptic vesicle exocytosis 3 1.2448132780082988 0.030511076851632932 CPLX3, RIMS1, PCLO 211 22 16792 10.852218871176218 1.0 0.7586466621291506 40.16051920234573 KEGG_PATHWAY hsa05202:Transcriptional misregulation in cancer 7 2.904564315352697 0.03167759654057991 RUNX1T1, FOXO1, IGF1, GRIA3, NR4A3, HMGA2, HPGD 99 168 6910 2.9082491582491583 0.9968553203252406 0.6172374825672946 32.708291712145744 GOTERM_BP_DIRECT GO:0008284~positive regulation of cell proliferation 12 4.979253112033195 0.03298932061482419 EGFR, CGA, STOX1, IRS2, AGTR2, ATF3, TBX3, BNC1, IGF1, PAK1, GDNF, ADCYAP1 211 466 16792 2.049346052925981 1.0 0.7751399680238791 42.64560955559533 GOTERM_MF_DIRECT GO:0005249~voltage-gated potassium channel activity 4 1.6597510373443984 0.033428592042144344 KCNMA1, KCNQ3, KCNE4, KCNH5 206 58 16881 5.651489789086039 0.9999997125003834 0.7149727129304251 38.20067584786941 GOTERM_BP_DIRECT GO:0032922~circadian regulation of gene expression 4 1.6597510373443984 0.03444129888157676 NPAS2, PER2, RORA, PPARGC1A 211 57 16792 5.584767606219341 1.0 0.7798101963504508 44.056200771094765 GOTERM_BP_DIRECT GO:0043065~positive regulation of apoptotic process 9 3.7344398340248963 0.035322936688818 KCNMA1, KNG1, TNFSF10, CSRNP3, SCIN, GRIN2A, FOXO1, WNT11, HMGA2 211 300 16792 2.387488151658768 1.0 0.7787239195189614 44.89673270222393 GOTERM_CC_DIRECT GO:0005927~muscle tendon junction 2 0.8298755186721992 0.036264427029565206 SMPX, CIB2 224 3 18224 54.238095238095234 0.9998102287472739 0.39595071039265395 37.76292467691656 GOTERM_MF_DIRECT GO:0005518~collagen binding 4 1.6597510373443984 0.036432230595367314 PODN, PAK1, ANTXR1, ABI3BP 206 60 16881 5.463106796116505 0.9999999275825403 0.7176699039459785 40.86420342064483 GOTERM_CC_DIRECT GO:0005576~extracellular region 29 12.033195020746888 0.036916164078112934 GC, NXPH2, CGA, NOG, C3, FST, GDNF, AHSG, FAM19A5, ADCYAP1, FGG, APOB, AGTR2, CRB1, FGB, ALB, APOH, CFH, ITIH3, THBS2, KNG1, IGF1, B3GAT1, TNFSF10, PTGDS, CCDC70, ANOS1, WNT11, TLL2 224 1610 18224 1.4654392191659273 0.9998377929308571 0.3841877540624281 38.30110534297659 GOTERM_BP_DIRECT GO:0072300~positive regulation of metanephric glomerulus development 2 0.8298755186721992 0.037052803771733415 RET, AGTR2 211 3 16792 53.055292259083735 1.0 0.7855405008908746 46.511576754142624 GOTERM_BP_DIRECT GO:0002331~pre-B cell allelic exclusion 2 0.8298755186721992 0.037052803771733415 RAG1, RAG2 211 3 16792 53.055292259083735 1.0 0.7855405008908746 46.511576754142624 GOTERM_BP_DIRECT GO:0033590~response to cobalamin 2 0.8298755186721992 0.037052803771733415 EGFR, CYTB 211 3 16792 53.055292259083735 1.0 0.7855405008908746 46.511576754142624 GOTERM_BP_DIRECT GO:0060197~cloacal septation 2 0.8298755186721992 0.037052803771733415 TP63, WNT11 211 3 16792 53.055292259083735 1.0 0.7855405008908746 46.511576754142624 GOTERM_BP_DIRECT GO:0048661~positive regulation of smooth muscle cell proliferation 4 1.6597510373443984 0.039209516352255155 EGFR, IGF1, NR4A3, PPARGC1A 211 60 16792 5.305529225908373 1.0 0.79545839867928 48.46262571011367 GOTERM_MF_DIRECT GO:0050839~cell adhesion molecule binding 4 1.6597510373443984 0.03956986141609243 FGG, FGB, NLGN1, CDHR5 206 62 16881 5.286877544628875 0.9999999829257951 0.7212806131586047 43.53233314870513 GOTERM_BP_DIRECT GO:0009967~positive regulation of signal transduction 4 1.6597510373443984 0.040869631543226786 SORBS1, SH3BGR, GRB14, TOB1 211 61 16792 5.218553336959055 1.0 0.8005175477878954 49.918669644985854 GOTERM_BP_DIRECT GO:0051965~positive regulation of synapse assembly 4 1.6597510373443984 0.04256478622659774 SLITRK4, CLSTN2, NLGN1, THBS2 211 62 16792 5.134383121846812 1.0 0.805491623754998 51.36549801553302 GOTERM_BP_DIRECT GO:0032981~mitochondrial respiratory chain complex I assembly 4 1.6597510373443984 0.04429477281047125 ND1, ND4, ND5, ND2 211 63 16792 5.0528849770555935 1.0 0.8103777120900599 52.8014970320947 GOTERM_BP_DIRECT GO:0033077~T cell differentiation in thymus 3 1.2448132780082988 0.04451933040969538 MAFB, RAG1, RAG2 211 27 16792 8.842548709847287 1.0 0.8041842011185591 52.984945134907676 GOTERM_BP_DIRECT GO:0032275~luteinizing hormone secretion 2 0.8298755186721992 0.04909753015126246 CGA, TBX3 211 4 16792 39.7914691943128 1.0 0.8278923067203134 56.58209447393914 GOTERM_BP_DIRECT GO:0072378~blood coagulation, fibrin clot formation 2 0.8298755186721992 0.04909753015126246 FGG, FGB 211 4 16792 39.7914691943128 1.0 0.8278923067203134 56.58209447393914 GOTERM_BP_DIRECT GO:0048570~notochord morphogenesis 2 0.8298755186721992 0.04909753015126246 NOG, WNT11 211 4 16792 39.7914691943128 1.0 0.8278923067203134 56.58209447393914 GOTERM_BP_DIRECT GO:0002018~renin-angiotensin regulation of aldosterone production 2 0.8298755186721992 0.04909753015126246 AGTR1, AGTR2 211 4 16792 39.7914691943128 1.0 0.8278923067203134 56.58209447393914 GOTERM_BP_DIRECT GO:0060513~prostatic bud formation 2 0.8298755186721992 0.04909753015126246 NOG, TP63 211 4 16792 39.7914691943128 1.0 0.8278923067203134 56.58209447393914 GOTERM_BP_DIRECT GO:0060244~negative regulation of cell proliferation involved in contact inhibition 2 0.8298755186721992 0.04909753015126246 SRPX, PAK1 211 4 16792 39.7914691943128 1.0 0.8278923067203134 56.58209447393914 GOTERM_BP_DIRECT GO:0071549~cellular response to dexamethasone stimulus 3 1.2448132780082988 0.050670155219904124 EGFR, AGTR2, FOXO1 211 29 16792 8.232717764340578 1.0 0.8305539421578065 57.756857558160426 GOTERM_BP_DIRECT GO:0060412~ventricular septum morphogenesis 3 1.2448132780082988 0.050670155219904124 NOG, TBX3, WNT11 211 29 16792 8.232717764340578 1.0 0.8305539421578065 57.756857558160426 GOTERM_BP_DIRECT GO:0045909~positive regulation of vasodilation 3 1.2448132780082988 0.050670155219904124 EGFR, AGTR2, ADCYAP1 211 29 16792 8.232717764340578 1.0 0.8305539421578065 57.756857558160426 GOTERM_MF_DIRECT GO:0005088~Ras guanyl-nucleotide exchange factor activity 5 2.0746887966804977 0.05162109564890809 EGFR, IRS2, RET, GRIN2A, GDNF 206 115 16881 3.5628957365977207 0.9999999999364706 0.790974949386192 52.77474747357962 GOTERM_BP_DIRECT GO:0043547~positive regulation of GTPase activity 13 5.394190871369295 0.05227476264656012 ALDH1A1, EGFR, IRS2, RET, RPGR, GRIN2A, RGS6, SIPA1L2, RGS7, WNT11, GDNF, ELMOD1, ADCYAP1 211 565 16792 1.8311118567294382 1.0 0.8332593077874583 58.92468129989512 GOTERM_BP_DIRECT GO:0090090~negative regulation of canonical Wnt signaling pathway 6 2.4896265560165975 0.05411826128308394 EGR1, NOG, AMER2, FOXO1, WNT11, SNAI2 211 163 16792 2.9294333149187333 1.0 0.8371663874291075 60.22890396179426 GOTERM_MF_DIRECT GO:0005158~insulin receptor binding 3 1.2448132780082988 0.05420981887340638 IRS2, SORBS1, IGF1 206 31 16881 7.930316316943314 0.9999999999810724 0.7862930959328832 54.567054545328055 GOTERM_MF_DIRECT GO:0004945~angiotensin type II receptor activity 2 0.8298755186721992 0.059269077763757894 AGTR1, AGTR2 206 5 16881 32.77864077669903 0.9999999999982413 0.7965114136285105 57.888756421953026 GOTERM_MF_DIRECT GO:0022851~GABA-gated chloride ion channel activity 2 0.8298755186721992 0.059269077763757894 GABRE, GABRB3 206 5 16881 32.77864077669903 0.9999999999982413 0.7965114136285105 57.888756421953026 GOTERM_BP_DIRECT GO:0060676~ureteric bud formation 2 0.8298755186721992 0.06099230729461925 NOG, GDNF 211 5 16792 31.833175355450237 1.0 0.8657886015725389 64.75702899635274 GOTERM_BP_DIRECT GO:0034392~negative regulation of smooth muscle cell apoptotic process 2 0.8298755186721992 0.06099230729461925 APOH, IGF1 211 5 16792 31.833175355450237 1.0 0.8657886015725389 64.75702899635274 GOTERM_BP_DIRECT GO:0061624~fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate 2 0.8298755186721992 0.06099230729461925 ALDH1A1, ALDOB 211 5 16792 31.833175355450237 1.0 0.8657886015725389 64.75702899635274 GOTERM_BP_DIRECT GO:0030540~female genitalia development 2 0.8298755186721992 0.06099230729461925 TBX3, SRD5A2 211 5 16792 31.833175355450237 1.0 0.8657886015725389 64.75702899635274 GOTERM_BP_DIRECT GO:0042773~ATP synthesis coupled electron transport 2 0.8298755186721992 0.06099230729461925 ND4, ND5 211 5 16792 31.833175355450237 1.0 0.8657886015725389 64.75702899635274 GOTERM_BP_DIRECT GO:0010828~positive regulation of glucose transport 2 0.8298755186721992 0.06099230729461925 C3, NR4A3 211 5 16792 31.833175355450237 1.0 0.8657886015725389 64.75702899635274 KEGG_PATHWAY hsa04924:Renin secretion 4 1.6597510373443984 0.06197393908880592 KCNMA1, AGTR1, GUCY1A2, ADCYAP1 99 64 6910 4.362373737373738 0.9999893715999595 0.8052419519543322 54.493233448726656 GOTERM_BP_DIRECT GO:1902042~negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 3 1.2448132780082988 0.06380796641350137 FGG, TNFSF10, FGB 211 33 16792 7.234812580784144 1.0 0.8724702947661848 66.4680252057886 GOTERM_BP_DIRECT GO:0002931~response to ischemia 3 1.2448132780082988 0.06380796641350137 EGR1, PER2, PPARGC1A 211 33 16792 7.234812580784144 1.0 0.8724702947661848 66.4680252057886 GOTERM_CC_DIRECT GO:0005938~cell cortex 5 2.0746887966804977 0.06448253843881968 STOX1, FGG, HMCN1, FGB, SCIN 224 123 18224 3.307200929152149 0.9999998076729572 0.5568727683669314 57.502804149132935 GOTERM_BP_DIRECT GO:0001666~response to hypoxia 6 2.4896265560165975 0.06508762964386859 KCNMA1, EGR1, ND4, ND5, CYTB, PAK1 211 172 16792 2.776149013556706 1.0 0.8723335207320474 67.21956074671394 GOTERM_MF_DIRECT GO:0005102~receptor binding 9 3.7344398340248963 0.06673061900413987 KNG1, NXPH2, FGG, TNFSF10, FGB, C3, CCDC129, GDNF, ADCYAP1 206 353 16881 2.0892901344921477 0.9999999999999484 0.8172575776991313 62.37783882983731 GOTERM_BP_DIRECT GO:0042391~regulation of membrane potential 4 1.6597510373443984 0.06768134996476907 KCNMA1, SLC26A8, RIMS1, KCNH5 211 75 16792 4.2444233807266984 1.0 0.8774894674783997 68.69454259238294 GOTERM_BP_DIRECT GO:0007623~circadian rhythm 4 1.6597510373443984 0.06768134996476907 EGFR, NPAS2, PER2, PPARGC1A 211 75 16792 4.2444233807266984 1.0 0.8774894674783997 68.69454259238294 GOTERM_BP_DIRECT GO:0060021~palate development 4 1.6597510373443984 0.06984055103794642 TBX3, GABRB3, WNT11, SNAI2 211 76 16792 4.188575704664506 1.0 0.8806437053531779 69.8746204264094 GOTERM_MF_DIRECT GO:0005251~delayed rectifier potassium channel activity 3 1.2448132780082988 0.07063581404171008 KCNA10, KCNS2, KCNQ3 206 36 16881 6.8288834951456305 0.9999999999999919 0.8187700798838595 64.54594288759945 GOTERM_CC_DIRECT GO:0016323~basolateral plasma membrane 6 2.4896265560165975 0.07064403919777698 KCNJ16, EGFR, TRPC4, MEGF11, HPGD, PIANP 224 180 18224 2.7119047619047616 0.9999999584812181 0.5725235145050764 60.959329563692 KEGG_PATHWAY hsa04710:Circadian rhythm 3 1.2448132780082988 0.07097723738599218 NPAS2, PER2, RORA 99 31 6910 6.75464320625611 0.9999981088866656 0.8074295281212366 59.58602263646108 KEGG_PATHWAY hsa00514:Other types of O-glycan biosynthesis 3 1.2448132780082988 0.07097723738599218 B3GAT1, FUT9, ST6GAL2 99 31 6910 6.75464320625611 0.9999981088866656 0.8074295281212366 59.58602263646108 GOTERM_BP_DIRECT GO:0032869~cellular response to insulin stimulus 4 1.6597510373443984 0.07203064811958469 IRS2, SORBS1, FOXO1, PAK1 211 77 16792 4.1341786175909405 1.0 0.8837272602123162 71.02879225665477 GOTERM_BP_DIRECT GO:0033603~positive regulation of dopamine secretion 2 0.8298755186721992 0.07273899314741528 NPY2R, GDNF 211 6 16792 26.527646129541868 1.0 0.8813993272332763 71.39310480224003 GOTERM_BP_DIRECT GO:0046321~positive regulation of fatty acid oxidation 2 0.8298755186721992 0.07273899314741528 NR4A3, PPARGC1A 211 6 16792 26.527646129541868 1.0 0.8813993272332763 71.39310480224003 GOTERM_BP_DIRECT GO:0061037~negative regulation of cartilage development 2 0.8298755186721992 0.07273899314741528 NOG, WNT11 211 6 16792 26.527646129541868 1.0 0.8813993272332763 71.39310480224003 GOTERM_BP_DIRECT GO:0050714~positive regulation of protein secretion 3 1.2448132780082988 0.07432459210861106 FGG, FGB, IGF1 211 36 16792 6.631911532385466 1.0 0.8822475372180059 72.19305879114243 GOTERM_CC_DIRECT GO:0010008~endosome membrane 6 2.4896265560165975 0.0773884375828992 EGFR, APOB, RET, ANTXR1, STEAP1, GRB14 224 185 18224 2.6386100386100386 0.9999999923372761 0.5892835892717697 64.44442363968801 KEGG_PATHWAY hsa04520:Adherens junction 4 1.6597510373443984 0.07930168884463695 EGFR, SORBS1, WASL, SNAI2 99 71 6910 3.932280551998862 0.9999996224234382 0.8066545786403582 63.823441872996575 GOTERM_MF_DIRECT GO:0005516~calmodulin binding 6 2.4896265560165975 0.08115262183442182 SLC8A3, EGFR, KCNQ3, RRAD, DCX, KCNH5 206 189 16881 2.601479426722145 1.0 0.8465945188709066 69.82111470420413 GOTERM_BP_DIRECT GO:0001942~hair follicle development 3 1.2448132780082988 0.0816207189661108 EGFR, LDB2, LGR5 211 38 16792 6.282863556996757 1.0 0.9012019610521338 75.61060689156032 GOTERM_BP_DIRECT GO:0001568~blood vessel development 3 1.2448132780082988 0.0816207189661108 TBX3, FOXO1, ANTXR1 211 38 16792 6.282863556996757 1.0 0.9012019610521338 75.61060689156032 GOTERM_BP_DIRECT GO:0060291~long-term synaptic potentiation 3 1.2448132780082988 0.0816207189661108 SLC8A3, NLGN1, GRIN2A 211 38 16792 6.282863556996757 1.0 0.9012019610521338 75.61060689156032 GOTERM_BP_DIRECT GO:0043524~negative regulation of neuron apoptotic process 5 2.0746887966804977 0.08397190288585807 GABRB3, GABRB2, NR4A3, GDNF, PPARGC1A 211 132 16792 3.014505241993393 1.0 0.903769862332323 76.62499831417132 GOTERM_BP_DIRECT GO:0060119~inner ear receptor cell development 2 0.8298755186721992 0.08433942275986651 GABRB3, GABRB2 211 7 16792 22.737982396750173 1.0 0.9007117895808209 76.77993101486908 GOTERM_BP_DIRECT GO:0006548~histidine catabolic process 2 0.8298755186721992 0.08433942275986651 AMDHD1, HNMT 211 7 16792 22.737982396750173 1.0 0.9007117895808209 76.77993101486908 GOTERM_BP_DIRECT GO:0045722~positive regulation of gluconeogenesis 2 0.8298755186721992 0.08433942275986651 FOXO1, PPARGC1A 211 7 16792 22.737982396750173 1.0 0.9007117895808209 76.77993101486908 GOTERM_MF_DIRECT GO:0004866~endopeptidase inhibitor activity 3 1.2448132780082988 0.08477955949795943 C3, ITIH3, AHSG 206 40 16881 6.145995145631068 1.0 0.8456965222059969 71.46425181288684 GOTERM_BP_DIRECT GO:0007605~sensory perception of sound 5 2.0746887966804977 0.08577247560651455 USP53, GABRB3, GABRB2, PCDH15, SNAI2 211 133 16792 2.9918397890460744 1.0 0.9006936057860446 77.37488400466545 GOTERM_CC_DIRECT GO:0042383~sarcolemma 4 1.6597510373443984 0.08625679243628777 SLC8A3, PGM5, SYNM, CIB2 224 85 18224 3.8285714285714287 0.9999999991849101 0.6137460117319857 68.59092240168252 KEGG_PATHWAY hsa04022:cGMP-PKG signaling pathway 6 2.4896265560165975 0.08634080665601221 SLC8A3, KCNMA1, AGTR1, IRS2, GUCY1A2, ADRA1B 99 166 6910 2.522818546914933 0.9999999044178266 0.8013732712344273 67.08379043519612 GOTERM_CC_DIRECT GO:0005874~microtubule 8 3.319502074688797 0.08844682293382003 SLC8A3, TPPP3, SPAG6, SYBU, PTPN20, KIF21A, DCX, KIF26B 224 311 18224 2.092788240698208 0.9999999995328825 0.6070630461497248 69.54378815492032 GOTERM_BP_DIRECT GO:0046426~negative regulation of JAK-STAT cascade 3 1.2448132780082988 0.08912676437305922 PODN, LRRTM4, HMGA2 211 40 16792 5.968720379146919 1.0 0.905839986028602 78.7119418682331 GOTERM_BP_DIRECT GO:0048839~inner ear development 3 1.2448132780082988 0.09295384985311587 STOX1, PCDH15, LGR5 211 41 16792 5.823141833314067 1.0 0.911740465813952 80.14667927061416 GOTERM_BP_DIRECT GO:0001501~skeletal system development 5 2.0746887966804977 0.09316125531124801 NOG, TBX3, TP63, IGF1, AHSG 211 137 16792 2.9044868025045836 1.0 0.9086092359835986 80.22177694213002 KEGG_PATHWAY hsa04152:AMPK signaling pathway 5 2.0746887966804977 0.09462216361824032 IRS2, CAB39L, FOXO1, IGF1, PPARGC1A 99 122 6910 2.8605729425401556 0.9999999812697006 0.8016171772193859 70.57291428024278 GOTERM_BP_DIRECT GO:0090277~positive regulation of peptide hormone secretion 2 0.8298755186721992 0.09579540853661968 FGG, FGB 211 8 16792 19.8957345971564 1.0 0.9113796960239979 81.15262575918845 GOTERM_BP_DIRECT GO:0046903~secretion 2 0.8298755186721992 0.09579540853661968 NPY2R, RIMS1 211 8 16792 19.8957345971564 1.0 0.9113796960239979 81.15262575918845 GOTERM_BP_DIRECT GO:0071420~cellular response to histamine 2 0.8298755186721992 0.09579540853661968 GABRB3, GABRB2 211 8 16792 19.8957345971564 1.0 0.9113796960239979 81.15262575918845 GOTERM_BP_DIRECT GO:0045599~negative regulation of fat cell differentiation 3 1.2448132780082988 0.09682790286541519 RUNX1T1, FOXO1, RORA 211 42 16792 5.684495599187541 1.0 0.9103067290029647 81.50612658960209 GOTERM_MF_DIRECT GO:0016491~oxidoreductase activity 6 2.4896265560165975 0.09708310668334527 ALDH1A1, AIFM3, ADHFE1, CYTB, HPGD, STEAP1 206 200 16881 2.458398058252427 1.0 0.8720891036520008 76.43941694705353