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Konstantinos Koussis, Evi Goulielmaki, Anna Chalari, Chrislaine Withers-Martinez, Inga Siden-Kiamos, Kai Matuschewski, Thanasis G. Loukeris
Targeted Deletion of a Plasmodium Site-2 Protease Impairs Life Cycle Progression in the Mammalian Host
www.plosone.org
www.plosone.org
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(1)Tj
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(nucleus)Tj
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(initiate)Tj
3.1009 0 Td
(tran-)Tj
-35.359 -1.2982 Td
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(of)Tj
1.0318 0 Td
(ER)Tj
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(chaperone)Tj
4.4787 0 Td
(genes)Tj
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([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.287 0 Td
(12)Tj
0 g
(].)Tj
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3.05 0 Td
(have)Tj
2.0977 0 Td
(shown)Tj
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(that)Tj
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(homologues)Tj
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(ATF6,)Tj
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(such)Tj
2.0919 0 Td
(as)Tj
1.0375 0 Td
(CREBH)Tj
3.4639 0 Td
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(liver)Tj
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1.0545 0 Td
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(RIP)Tj
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(medi-)Tj
-34.5031 -1.3039 Td
(ated)Tj
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(S1P/S2P)Tj
3.634 0 Td
(pair)Tj
1.8481 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7745 0 Td
(14)Tj
0 g
(].)Tj
/F14 1 Tf
-10.6922 -1.2983 Td
[()4()4()10( )6()4()12()12()12( )]TJ
/F7 1 Tf
5.2271 0 Td
(parasites,)Tj
4.0025 0 Td
(the)Tj
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(single)Tj
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(eukaryotes)Tj
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(that)Tj
1.8142 0 Td
(rely)Tj
-34.9113 -1.2982 Td
(on)Tj
1.2926 0 Td
(proteases)Tj
3.9968 0 Td
(to)Tj
1.0432 0 Td
(control)Tj
3.1861 0 Td
(essential)Tj
3.6623 0 Td
(biological)Tj
4.1783 0 Td
(functions)Tj
4.0705 0 Td
(ranging)Tj
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(parasite)Tj
3.3958 0 Td
(development)Tj
5.5105 0 Td
(and)Tj
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(haemoglobin)Tj
5.5729 0 Td
(degradation)Tj
5.1193 0 Td
(to)Tj
1.0432 0 Td
(invasion)Tj
3.6793 0 Td
(and)Tj
1.7575 0 Td
(egress)Tj
2.6815 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7745 0 Td
(16)Tj
0 g
(].)Tj
/F14 1 Tf
1.7688 0 Td
[()4()4()10( )6()4()12()12()12( )]TJ
/F7 1 Tf
5.2214 0 Td
(genomes)Tj
3.8324 0 Td
(encode)Tj
-32.4508 -1.2983 Td
(three)Tj
2.3074 0 Td
(i-CLiP)Tj
2.9196 0 Td
(families,)Tj
3.634 0 Td
(while)Tj
/F8 1 Tf
2.4151 0 Td
(\r)Tj
/F7 1 Tf
(-secretases)Tj
5.0117 0 Td
(have)Tj
2.0976 0 Td
(not)Tj
1.5987 0 Td
(yet)Tj
1.423 0 Td
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2.16 0 Td
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4.3823 0 Td
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1.8085 0 Td
(Rhomboid)Tj
4.5751 0 Td
(family)Tj
-34.333 -1.2983 Td
(of)Tj
1.0318 0 Td
(i-CLiPs)Tj
3.2882 0 Td
(in)Tj
/F14 1 Tf
1.0545 0 Td
[()4()4()10( )6()4()12()12()12( )]TJ
/F7 1 Tf
5.2213 0 Td
(and)Tj
1.7575 0 Td
(related)Tj
3.0104 0 Td
(apicomplexan)Tj
5.93 0 Td
(parasites)Tj
3.7644 0 Td
(has)Tj
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(been)Tj
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(extensively)Tj
4.6828 0 Td
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-33.4713 -1.2982 Td
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3.3789 0 Td
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1.0374 0 Td
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(importance)Tj
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(cell)Tj
1.5931 0 Td
(invasion)Tj
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(and)Tj
1.7575 0 Td
(egress)Tj
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([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
/F14 1 Tf
2.1203 0 Td
[()4()4()10( )6()4()12()12()12( )]TJ
/F7 1 Tf
5.2271 0 Td
(parasites)Tj
-31.5494 -1.304 Td
(encode)Tj
3.1238 0 Td
(eight)Tj
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(rhomboids.)Tj
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(ROM1)Tj
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(ROM4)Tj
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(known)Tj
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3.0501 0 Td
[()12()]TJ
1.0375 0 Td
[()-13()14()7()20()]TJ
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1.0431 0 Td
(cleave)Tj
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(different)Tj
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(adhesins)Tj
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([)Tj
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(18)Tj
0 g
()Tj
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(20)Tj
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(].)Tj
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(the)Tj
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(mouse)Tj
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(malaria)Tj
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-34.0439 -1.3039 Td
[()4()4()10( )6()4()12()12()12( )]TJ
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[(\r)4()2()6()-2()6()2()]TJ
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[()8()13()]TJ
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(,)Tj
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3.1124 0 Td
[()8()13()]TJ
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(,)Tj
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3.1124 0 Td
[()8()13()]TJ
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2.88 0 Td
(and)Tj
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1.7575 0 Td
[()8()13()]TJ
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(].)Tj
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[()]TJ
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(intra-erythrocytic)Tj
7.472 0 Td
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Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 253.1905 745.7952 cm
BT
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3.5646 0 Td
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ET
Q
q
1 j
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36 48.0002 m
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576 47.5002 l
36 47.5002 l
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BT
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(ONE)Tj
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(DOI:10.137)Tj
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2.0622 0 Td
(\(ESF\))Tj
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(the)Tj
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(eness)Tj
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(2007-2013\))Tj
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