Annotation Cluster 1 Enrichment Score: 13.47338693208272 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006414~translational elongation 17 20.0 1.9882422551926943E-19 RPL18, RPL14, RPL15, RPL27A, RPL24, RPS2, RPL28, RPL30, RPL32, RPL6, RPL34, RPS15, RPL8, RPL3, RPL7A, RPL12, RPL4 77 101 13528 29.571299987141572 2.12543097080099E-16 2.12543097080099E-16 3.1680755987835485E-16 GOTERM_BP_FAT GO:0006412~translation 24 28.235294117647058 2.0230173578991902E-19 ABCF1, RPL18, RPL14, RPL15, RPL27A, GARS, EIF2S3, RPL24, RPS2, RPL28, RPL30, RPL32, EIF3G, GSPT1, RPL6, RPL34, EEF1E1, RPS15, RPL8, RPL3, RPL4, RPL12, RPL7A, FARSA 77 331 13528 12.738729548397222 2.1626055555942343E-16 1.0813027777971172E-16 3.223486429149874E-16 GOTERM_CC_FAT GO:0022625~cytosolic large ribosomal subunit 13 15.294117647058824 3.060924852551126E-18 RPL18, RPL30, RPL32, RPL14, RPL6, RPL34, RPL8, RPL3, RPL27A, RPL24, RPL7A, RPL4, RPL28 80 38 12782 54.659868421052636 6.397332941831854E-16 3.198666470915927E-16 3.8641927464955214E-15 GOTERM_CC_FAT GO:0022626~cytosolic ribosome 15 17.647058823529413 4.549626470755026E-17 RPL18, RPL30, RPL32, RPL14, RPL6, RPL34, RPS15, RPL8, RPL27A, RPL3, RPL24, RPL4, RPL7A, RPS2, RPL28 80 81 12782 29.587962962962965 9.508719323878004E-15 3.1695731079593353E-15 5.743569167633443E-14 SP_PIR_KEYWORDS protein biosynthesis 17 20.0 1.2530186880524991E-16 RPL18, GARS, EIF2S3, RPL24, RPS2, RPL30, RPL32, EIF3G, GSPT1, RPL6, EEF1E1, RPS15, RPL8, RPL3, RPL7A, FARSA, RPL12 85 188 19235 20.46276595744681 2.1316282072803006E-14 1.0658141036401503E-14 1.3322676295501878E-13 SP_PIR_KEYWORDS ribosomal protein 17 20.0 1.2530186880524991E-16 RPL18, RPL14, RPL15, RPL27A, RPL24, RPS2, RPL28, RPL30, RPL32, RPL6, RPL34, RPS15, RPL8, RPL3, RPL7A, RPL12, RPL4 85 188 19235 20.46276595744681 2.1316282072803006E-14 1.0658141036401503E-14 1.3322676295501878E-13 SP_PIR_KEYWORDS ribonucleoprotein 19 22.35294117647059 1.7902004475055012E-16 RPL18, RPL14, RPL15, RPL27A, RPL24, SSB, RPS2, RPL28, HNRNPA3, RPL30, RPL32, RPL6, RPL34, RPS15, RPL8, RPL3, RPL4, RPL7A, RPL12 85 279 19235 15.410710520767447 4.263256414560601E-14 1.4210854715202004E-14 2.7755575615628914E-13 KEGG_PATHWAY hsa03010:Ribosome 17 20.0 2.174779238315002E-16 RPL18, RPL14, RPL15, RPL27A, RPL24, RPS2, RPL28, RPL30, RPL32, RPL6, RPL34, RPS15, RPL8, RPL3, RPL7A, RPL12, RPL4 56 87 5085 17.74322660098522 1.509903313490213E-14 1.509903313490213E-14 2.3314683517128287E-13 GOTERM_CC_FAT GO:0005840~ribosome 19 22.35294117647059 6.015357488221087E-16 ABCF1, RPL18, RPL14, RPL15, RPL27A, RPL24, RPS2, RPL28, RPL30, RPL32, RPL6, RPL34, RPS15, RPL8, RPL3, RPL4, RPL7A, RPL12, APEX1 80 215 12782 14.119651162790696 1.1601830607332886E-13 2.8976820942716586E-14 6.994405055138486E-13 GOTERM_MF_FAT GO:0003735~structural constituent of ribosome 17 20.0 1.7011015494536415E-15 RPL18, RPL14, RPL15, RPL27A, RPL24, RPS2, RPL28, RPL30, RPL32, RPL6, RPL34, RPS15, RPL8, RPL3, RPL7A, RPL12, RPL4 77 168 12983 17.061765615337045 4.0967229608668276E-13 4.0967229608668276E-13 2.1538326677728037E-12 GOTERM_CC_FAT GO:0015934~large ribosomal subunit 13 15.294117647058824 5.928803318778878E-15 RPL18, RPL30, RPL32, RPL14, RPL6, RPL34, RPL8, RPL3, RPL27A, RPL24, RPL7A, RPL4, RPL28 80 67 12782 31.001119402985076 1.229794044377286E-12 2.4591439995447217E-13 7.427392034742297E-12 SP_PIR_KEYWORDS ribosome 12 14.117647058823529 1.5998915839989032E-14 RPL18, RPL30, RPL32, RPL6, RPL8, RPS15, RPL3, RPL24, RPL7A, RPL4, RPL12, RPS2 85 73 19235 37.19903303787268 3.069544618483633E-12 7.673861546209082E-13 1.9906298831529057E-11 GOTERM_CC_FAT GO:0033279~ribosomal subunit 15 17.647058823529413 3.541304516991245E-14 RPL18, RPL30, RPL32, RPL14, RPL6, RPL34, RPS15, RPL8, RPL27A, RPL3, RPL24, RPL4, RPL7A, RPS2, RPL28 80 128 12782 18.7236328125 7.401967927478381E-12 1.233679824963474E-12 4.4708681201655054E-11 GOTERM_CC_FAT GO:0044445~cytosolic part 15 17.647058823529413 3.9530253471854874E-13 RPL18, RPL30, RPL32, RPL14, RPL6, RPL34, RPS15, RPL8, RPL27A, RPL3, RPL24, RPL4, RPL7A, RPS2, RPL28 80 152 12782 15.767269736842104 8.262823758542481E-11 1.1804002220117127E-11 4.991007607202391E-10 GOTERM_MF_FAT GO:0005198~structural molecule activity 23 27.058823529411764 5.9909751203291865E-12 RPL18, COPA, TNXB, RPL14, ELN, RPL15, RPL27A, RPL24, RPS2, RPL28, RPL30, FBLN1, RPL32, RPL6, RPL34, COPB1, RPS15, RPL8, MYBPH, RPL3, RPL4, RPL12, RPL7A 77 634 12983 6.116780695645049 1.4737824294286384E-9 7.368912147143192E-10 7.763112375158698E-9 GOTERM_CC_FAT GO:0030529~ribonucleoprotein complex 21 24.705882352941178 2.558051472730345E-11 ABCF1, RPL18, RPL14, RPL15, RPL27A, RPL24, SSB, RPS2, RPL28, HNRNPA3, RPL30, RPL32, RPL6, RPL34, RPS15, RPL8, RPL3, RPL4, RPL7A, RPL12, APEX1 80 515 12782 6.515097087378642 5.346332376809926E-9 6.682915332234529E-10 3.2293545615402763E-8 GOTERM_MF_FAT GO:0003723~RNA binding 20 23.52941176470588 1.9834087862691462E-8 RPL18, RPL14, RPL15, RPL27A, RPL24, SSB, RPS2, RPL28, HNRNPA3, SBDS, RPL30, EIF3G, RPL6, RPL34, RPL8, RPL3, RPL4, RPL7A, FARSA, RPL12 77 718 12983 4.696668234272691 4.879173748029153E-6 1.6263938945604295E-6 2.570098478482663E-5 GOTERM_CC_FAT GO:0043232~intracellular non-membrane-bounded organelle 32 37.64705882352941 8.464063794558857E-5 RPL18, ABCF1, RPL14, HINT1, RPL15, XRCC6, RPL27A, RPS2, HADHB, HNRNPA3, CTTN, SBDS, PFN2, RPL30, EZR, RPL32, RPL6, RPL34, MYBPH, RPL8, RPL3, RPL12, RPL4, RPL7A, APEX1, SSB, RPL24, NEXN, RPL28, TNNT1, RPS15, TOM1 80 2596 12782 1.969491525423729 0.017535081281170095 0.0019636963111365757 0.10680003744470978 GOTERM_CC_FAT GO:0043228~non-membrane-bounded organelle 32 37.64705882352941 8.464063794558857E-5 RPL18, ABCF1, RPL14, HINT1, RPL15, XRCC6, RPL27A, RPS2, HADHB, HNRNPA3, CTTN, SBDS, PFN2, RPL30, EZR, RPL32, RPL6, RPL34, MYBPH, RPL8, RPL3, RPL12, RPL4, RPL7A, APEX1, SSB, RPL24, NEXN, RPL28, TNNT1, RPS15, TOM1 80 2596 12782 1.969491525423729 0.017535081281170095 0.0019636963111365757 0.10680003744470978 Annotation Cluster 2 Enrichment Score: 1.8737391646959443 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS extracellular matrix 8 9.411764705882353 8.863902025734687E-5 FBLN1, TNXB, LGALS1, ELN, CCDC80, NID2, TIMP3, MMP2 85 241 19235 7.511837930192824 0.01687543358209509 0.002832555089836042 0.11030089146000233 GOTERM_BP_FAT GO:0030198~extracellular matrix organization 3 3.5294117647058822 0.11583253811208728 TNXB, ELN, CCDC80 77 104 13528 5.067932067932068 1.0 0.8638488300437873 85.93698685590655 GOTERM_BP_FAT GO:0043062~extracellular structure organization 3 3.5294117647058822 0.23298447689691504 TNXB, ELN, CCDC80 77 163 13528 3.2335272089873315 1.0 0.958661424621512 98.53962845825174 Annotation Cluster 3 Enrichment Score: 1.8420536240971144 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0016197~endosome transport 4 4.705882352941177 0.00421233564983706 AP2A1, RAB14, TOM1, EHD1 77 58 13528 12.116435288849082 0.9890289750103669 0.3365004159571183 6.504917035497626 GOTERM_CC_FAT GO:0005769~early endosome 4 4.705882352941177 0.015614726001005165 RAB14, TOM1, EHD1, B2M 80 85 12782 7.518823529411765 0.9627172776846565 0.1449794495185086 18.018754391209956 GOTERM_CC_FAT GO:0005768~endosome 6 7.0588235294117645 0.045267008024238636 STX7, ATP6V1E1, RAB14, TOM1, EHD1, B2M 80 315 12782 3.043333333333333 0.999937580044494 0.2758240209395225 44.27832643557916 Annotation Cluster 4 Enrichment Score: 1.6288173673950503 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0016197~endosome transport 4 4.705882352941177 0.00421233564983706 AP2A1, RAB14, TOM1, EHD1 77 58 13528 12.116435288849082 0.9890289750103669 0.3365004159571183 6.504917035497626 GOTERM_BP_FAT GO:0016044~membrane organization 8 9.411764705882353 0.005486788708419834 COPA, STX4, STX7, AP2A1, COPB1, TOM1, SNX3, EHD1 77 381 13528 3.6889934212768862 0.99720947986957 0.3076027688572911 8.393458679810983 SP_PIR_KEYWORDS protein transport 7 8.235294117647058 0.019400645104538115 COPA, SCAMP3, AP2A1, COPB1, RAB14, TOM1, SNX3 85 485 19235 3.266100667070952 0.9767518812782764 0.3135027822193299 21.644548822362452 GOTERM_BP_FAT GO:0010324~membrane invagination 4 4.705882352941177 0.1265108847604809 AP2A1, TOM1, SNX3, EHD1 77 220 13528 3.1943329397874853 1.0 0.8807294268234167 88.41238931151553 GOTERM_BP_FAT GO:0006897~endocytosis 4 4.705882352941177 0.1265108847604809 AP2A1, TOM1, SNX3, EHD1 77 220 13528 3.1943329397874853 1.0 0.8807294268234167 88.41238931151553 Annotation Cluster 5 Enrichment Score: 1.5363180531700331 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048193~Golgi vesicle transport 7 8.235294117647058 9.226245211089968E-5 COPA, STX4, SCAMP3, STX7, AP2A1, COPB1, RAB14 77 131 13528 9.387925052047189 0.0939249243739918 0.03234310689989073 0.14691023664336056 GOTERM_BP_FAT GO:0046907~intracellular transport 13 15.294117647058824 2.776912519080488E-4 COPA, SCAMP3, STX4, STX7, SLC25A6, SNAPIN, TGFB1, AP2A1, COPB1, RPS15, RAB14, TOM1, EHD1 77 657 13528 3.47632884619186 0.2568766058758377 0.07153564901710285 0.4415583905464482 GOTERM_BP_FAT GO:0006892~post-Golgi vesicle-mediated transport 5 5.88235294117647 3.1013645872087425E-4 STX4, SCAMP3, STX7, AP2A1, RAB14 77 58 13528 15.14554411106135 0.282216505920582 0.0641662718380216 0.49303029626367456 GOTERM_BP_FAT GO:0016192~vesicle-mediated transport 12 14.117647058823529 3.5077800815293785E-4 COPA, STX4, SCAMP3, STX7, AP2A1, COPB1, GARS, RAB14, TOM1, SNAPIN, SNX3, EHD1 77 576 13528 3.66017316017316 0.3127433486440907 0.060594370069577796 0.5574699019262108 GOTERM_CC_FAT GO:0044431~Golgi apparatus part 8 9.411764705882353 0.0022352291943284726 COPA, STX4, SCAMP3, AP2A1, COPB1, RAB14, TGFB1, B2M 80 294 12782 4.347619047619048 0.3735496696913835 0.03822410780454777 2.785441843604264 GOTERM_CC_FAT GO:0005798~Golgi-associated vesicle 4 4.705882352941177 0.0038233429775086014 COPA, AP2A1, COPB1, RAB14 80 51 12782 12.531372549019608 0.5509451161949008 0.05558202454249361 4.720871001189375 GOTERM_BP_FAT GO:0006886~intracellular protein transport 8 9.411764705882353 0.0049658273728891145 COPA, STX4, STX7, AP2A1, COPB1, TOM1, SNAPIN, TGFB1 77 374 13528 3.7580387526911596 0.9951155262688584 0.29867198855081123 7.625837040245431 GOTERM_BP_FAT GO:0016044~membrane organization 8 9.411764705882353 0.005486788708419834 COPA, STX4, STX7, AP2A1, COPB1, TOM1, SNX3, EHD1 77 381 13528 3.6889934212768862 0.99720947986957 0.3076027688572911 8.393458679810983 GOTERM_CC_FAT GO:0016023~cytoplasmic membrane-bounded vesicle 10 11.76470588235294 0.0066804335621540095 COPA, STX4, AP2A1, COPB1, GARS, RAB14, SNAPIN, ATP6V1B2, EHD1, TGFB1 80 550 12782 2.9050000000000002 0.7536236749543404 0.08916453661146817 8.113725994368115 GOTERM_CC_FAT GO:0031988~membrane-bounded vesicle 10 11.76470588235294 0.008181517962976042 COPA, STX4, AP2A1, COPB1, GARS, RAB14, SNAPIN, ATP6V1B2, EHD1, TGFB1 80 568 12782 2.8129401408450705 0.8203905637130641 0.10175342098450324 9.851375016081587 GOTERM_BP_FAT GO:0034613~cellular protein localization 8 9.411764705882353 0.00819761548181586 COPA, STX4, STX7, AP2A1, COPB1, TOM1, SNAPIN, TGFB1 77 411 13528 3.4197238284829528 0.999849171532729 0.38667097492123415 12.292219105650926 GOTERM_BP_FAT GO:0070727~cellular macromolecule localization 8 9.411764705882353 0.008514950489724133 COPA, STX4, STX7, AP2A1, COPB1, TOM1, SNAPIN, TGFB1 77 414 13528 3.3949432210301778 0.9998928688818148 0.3819150178932924 12.738306460237869 GOTERM_BP_FAT GO:0008104~protein localization 12 14.117647058823529 0.009922918482978615 COPA, STX4, SCAMP3, EZR, STX7, AP2A1, COPB1, RAB14, TOM1, SNAPIN, SNX3, TGFB1 77 882 13528 2.3903171658273696 0.9999765485868144 0.38403911087307985 14.692004138320481 GOTERM_BP_FAT GO:0015031~protein transport 11 12.941176470588237 0.009954693176804329 COPA, STX4, SCAMP3, STX7, AP2A1, COPB1, RAB14, TOM1, SNAPIN, SNX3, TGFB1 77 762 13528 2.536182977127859 0.9999773395157118 0.371861834164098 14.735617972874127 GOTERM_BP_FAT GO:0045184~establishment of protein localization 11 12.941176470588237 0.010575246108484095 COPA, STX4, SCAMP3, STX7, AP2A1, COPB1, RAB14, TOM1, SNAPIN, SNX3, TGFB1 77 769 13528 2.5130967861787106 0.9999884073484159 0.3772109769654949 15.583208690568684 GOTERM_CC_FAT GO:0009898~internal side of plasma membrane 7 8.235294117647058 0.013372140157778808 COPA, EZR, AP2A1, COPB1, RAB14, SNAPIN, EHD1 80 316 12782 3.5393196202531643 0.9400132539569802 0.13764294385103548 15.62949462660349 GOTERM_CC_FAT GO:0030660~Golgi-associated vesicle membrane 3 3.5294117647058822 0.01374568342349788 COPA, AP2A1, COPB1 80 29 12782 16.52844827586207 0.944577813420036 0.13466517349340212 16.03186765514777 GOTERM_BP_FAT GO:0007269~neurotransmitter secretion 3 3.5294117647058822 0.015557601205383052 STX4, RAB14, SNAPIN 77 34 13528 15.501909854851032 0.9999999474658894 0.4751720249532567 22.10778685029937 GOTERM_CC_FAT GO:0030135~coated vesicle 5 5.88235294117647 0.016842887103369418 COPA, AP2A1, COPB1, RAB14, SNAPIN 80 159 12782 5.02437106918239 0.9712795364419894 0.1490230573523872 19.300683725282152 GOTERM_CC_FAT GO:0031410~cytoplasmic vesicle 10 11.76470588235294 0.01720055162858663 COPA, STX4, AP2A1, COPB1, GARS, RAB14, SNAPIN, ATP6V1B2, EHD1, TGFB1 80 642 12782 2.4887071651090342 0.9733826420138184 0.14586029499291786 19.67052114233495 SP_PIR_KEYWORDS protein transport 7 8.235294117647058 0.019400645104538115 COPA, SCAMP3, AP2A1, COPB1, RAB14, TOM1, SNX3 85 485 19235 3.266100667070952 0.9767518812782764 0.3135027822193299 21.644548822362452 GOTERM_CC_FAT GO:0031982~vesicle 10 11.76470588235294 0.022042898948557918 COPA, STX4, AP2A1, COPB1, GARS, RAB14, SNAPIN, ATP6V1B2, EHD1, TGFB1 80 670 12782 2.3847014925373133 0.9905193276077219 0.17642789025757555 24.526473373249658 GOTERM_CC_FAT GO:0030120~vesicle coat 3 3.5294117647058822 0.02296602454955994 COPA, AP2A1, COPB1 80 38 12782 12.613815789473684 0.9922174802878785 0.17653563664145155 25.42093255279164 GOTERM_CC_FAT GO:0000139~Golgi membrane 5 5.88235294117647 0.02802417414858817 COPA, SCAMP3, AP2A1, COPB1, B2M 80 186 12782 4.29502688172043 0.9973697810334915 0.1975016564660489 30.151143926192113 SP_PIR_KEYWORDS transport 14 16.470588235294116 0.028649768012337543 COPA, SCAMP3, STX4, SLC12A2, SLC25A6, ATP6V1B2, SNX3, DBI, ATP2B4, AP2A1, COPB1, ATP6V1E1, RAB14, TOM1 85 1670 19235 1.897076435364565 0.9962315491010771 0.37192201398776004 30.365018514903618 GOTERM_CC_FAT GO:0005794~Golgi apparatus 11 12.941176470588237 0.041686112632733176 COPA, STX4, SCAMP3, STX7, AP2A1, COPB1, RAB14, ATP6V1B2, PTGFRN, TGFB1, B2M 80 872 12782 2.0155103211009178 0.9998635019689673 0.26425300652013606 41.581644061317036 GOTERM_BP_FAT GO:0001505~regulation of neurotransmitter levels 3 3.5294117647058822 0.05448049844918687 STX4, RAB14, SNAPIN 77 67 13528 7.866640821864703 1.0 0.7596987329375913 59.04260491970725 GOTERM_CC_FAT GO:0048475~coated membrane 3 3.5294117647058822 0.05782258014263277 COPA, AP2A1, COPB1 80 63 12782 7.6083333333333325 0.9999960759676557 0.3222740062062559 52.85406667371662 GOTERM_CC_FAT GO:0030117~membrane coat 3 3.5294117647058822 0.05782258014263277 COPA, AP2A1, COPB1 80 63 12782 7.6083333333333325 0.9999960759676557 0.3222740062062559 52.85406667371662 GOTERM_CC_FAT GO:0030662~coated vesicle membrane 3 3.5294117647058822 0.07482933279196058 COPA, AP2A1, COPB1 80 73 12782 6.566095890410959 0.9999999128298743 0.36335240620909315 62.539313314012546 GOTERM_BP_FAT GO:0006836~neurotransmitter transport 3 3.5294117647058822 0.07923093878954743 STX4, RAB14, SNAPIN 77 83 13528 6.350179940541386 1.0 0.8227562480200299 73.16042285204998 GOTERM_BP_FAT GO:0003001~generation of a signal involved in cell-cell signaling 3 3.5294117647058822 0.08253460537449976 STX4, RAB14, SNAPIN 77 85 13528 6.200763941940412 1.0 0.8240289795136813 74.6544218312435 GOTERM_BP_FAT GO:0046903~secretion 5 5.88235294117647 0.0882701164254989 COPA, STX4, GARS, RAB14, SNAPIN 77 300 13528 2.9281385281385277 1.0 0.8232680646044203 77.06462891265309 GOTERM_CC_FAT GO:0030141~secretory granule 4 4.705882352941177 0.10025731707655261 STX4, GARS, RAB14, TGFB1 80 180 12782 3.550555555555556 0.9999999997425283 0.4406923246991623 73.65018670930401 GOTERM_CC_FAT GO:0044433~cytoplasmic vesicle part 4 4.705882352941177 0.1091870698261945 COPA, AP2A1, COPB1, TGFB1 80 187 12782 3.4176470588235297 0.9999999999679829 0.4618452146647112 76.76773208239345 GOTERM_BP_FAT GO:0032940~secretion by cell 4 4.705882352941177 0.11069102001974765 STX4, GARS, RAB14, SNAPIN 77 207 13528 3.3949432210301778 1.0 0.8590644653119629 84.57579799033164 GOTERM_BP_FAT GO:0006887~exocytosis 3 3.5294117647058822 0.13642771046663144 STX4, GARS, SNAPIN 77 115 13528 4.58317334839074 1.0 0.893539103476661 90.33993323771293 GOTERM_CC_FAT GO:0030136~clathrin-coated vesicle 3 3.5294117647058822 0.1963408906860287 AP2A1, RAB14, SNAPIN 80 132 12782 3.6312499999999996 1.0 0.6376639196462641 93.66710741115328 GOTERM_CC_FAT GO:0030659~cytoplasmic vesicle membrane 3 3.5294117647058822 0.21213169691184236 COPA, AP2A1, COPB1 80 139 12782 3.4483812949640287 1.0 0.661515089595444 95.07049700480677 GOTERM_CC_FAT GO:0012506~vesicle membrane 3 3.5294117647058822 0.23946788085763263 COPA, AP2A1, COPB1 80 151 12782 3.1743377483443704 1.0 0.6963550637827245 96.84356727951979 SP_PIR_KEYWORDS cytoplasmic vesicle 3 3.5294117647058822 0.27882255884590956 COPA, COPB1, SNAPIN 85 238 19235 2.85244686109738 1.0 0.9423107382447101 98.29154399151703 GOTERM_BP_FAT GO:0019226~transmission of nerve impulse 4 4.705882352941177 0.31401786471820536 STX4, RAB14, SNAPIN, TGFB1 77 350 13528 2.007866419294991 1.0 0.9784469632375085 99.75350977964538 GOTERM_CC_FAT GO:0005773~vacuole 3 3.5294117647058822 0.4636063142332189 STX4, STX7, RAB14 80 252 12782 1.9020833333333331 1.0 0.9182039390186028 99.9615470281039 GOTERM_BP_FAT GO:0007268~synaptic transmission 3 3.5294117647058822 0.5016265801488564 STX4, RAB14, SNAPIN 77 298 13528 1.768674278741393 1.0 0.9980809912426194 99.99848356597066 GOTERM_CC_FAT GO:0031090~organelle membrane 8 9.411764705882353 0.5217649772869676 COPA, SCAMP3, STX7, AP2A1, COPB1, SLC25A6, B2M, HADHB 80 1096 12782 1.1662408759124088 1.0 0.9362653131612837 99.99096958404701 GOTERM_BP_FAT GO:0050877~neurological system process 8 9.411764705882353 0.5257971563490477 GPX1, STX4, SBDS, SLC12A2, RAB14, SNAPIN, TIMP3, TGFB1 77 1210 13528 1.1615756144681766 1.0 0.9987016832152478 99.99931325438129 GOTERM_CC_FAT GO:0012505~endomembrane system 6 7.0588235294117645 0.5349873353685949 COPA, SCAMP3, AP2A1, COPB1, RAB14, B2M 80 782 12782 1.2258951406649616 1.0 0.9366529290542778 99.99366149017538 GOTERM_BP_FAT GO:0007267~cell-cell signaling 4 4.705882352941177 0.6614057058428611 STX4, RAB14, MME, SNAPIN 77 600 13528 1.1712554112554112 1.0 0.9997726362451895 99.99999679453725 Annotation Cluster 6 Enrichment Score: 1.4240983564379575 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009150~purine ribonucleotide metabolic process 6 7.0588235294117645 0.0010621544942709532 ATP2B4, ATP6V1E1, ACLY, ATP6V1B2, NT5E, TGFB1 77 138 13528 7.638622247317899 0.6789140997841414 0.14980740257784964 1.679085524376367 GOTERM_BP_FAT GO:0009259~ribonucleotide metabolic process 6 7.0588235294117645 0.001407275105776906 ATP2B4, ATP6V1E1, ACLY, ATP6V1B2, NT5E, TGFB1 77 147 13528 7.170951497482109 0.7780796218531464 0.17153407980341762 2.2189497526327595 GOTERM_BP_FAT GO:0046034~ATP metabolic process 5 5.88235294117647 0.0028646998790661277 ATP2B4, ATP6V1E1, ACLY, ATP6V1B2, TGFB1 77 105 13528 8.366110080395794 0.953428147455639 0.2887640115758545 4.468273990032823 GOTERM_BP_FAT GO:0006163~purine nucleotide metabolic process 6 7.0588235294117645 0.00391103112794214 ATP2B4, ATP6V1E1, ACLY, ATP6V1B2, NT5E, TGFB1 77 186 13528 5.667364893171345 0.9848399174816145 0.3422359151195793 6.053128281215958 GOTERM_BP_FAT GO:0009205~purine ribonucleoside triphosphate metabolic process 5 5.88235294117647 0.004224022064626734 ATP2B4, ATP6V1E1, ACLY, ATP6V1B2, TGFB1 77 117 13528 7.5080475080475075 0.9891657543798063 0.31414355652744297 6.522399051181782 GOTERM_BP_FAT GO:0009199~ribonucleoside triphosphate metabolic process 5 5.88235294117647 0.004353882906374767 ATP2B4, ATP6V1E1, ACLY, ATP6V1B2, TGFB1 77 118 13528 7.444419986792868 0.9905756873164098 0.3014893165982183 6.7164552423900625 GOTERM_BP_FAT GO:0009144~purine nucleoside triphosphate metabolic process 5 5.88235294117647 0.004900300765961385 ATP2B4, ATP6V1E1, ACLY, ATP6V1B2, TGFB1 77 122 13528 7.200340642963592 0.9947592912071853 0.3127744655112328 7.528859758683404 GOTERM_BP_FAT GO:0009141~nucleoside triphosphate metabolic process 5 5.88235294117647 0.006294276887423667 ATP2B4, ATP6V1E1, ACLY, ATP6V1B2, TGFB1 77 131 13528 6.705660751462277 0.9988289412803973 0.32769947359547924 9.571463992050722 GOTERM_BP_FAT GO:0006164~purine nucleotide biosynthetic process 5 5.88235294117647 0.009600187664191266 ATP2B4, ATP6V1E1, ATP6V1B2, NT5E, TGFB1 77 148 13528 5.935415935415935 0.9999667740588091 0.38802030349487016 14.24783866966125 GOTERM_BP_FAT GO:0006754~ATP biosynthetic process 4 4.705882352941177 0.013698359828019742 ATP2B4, ATP6V1E1, ATP6V1B2, TGFB1 77 89 13528 7.896103896103897 0.9999996051533542 0.4455567020692949 19.730394512475268 GOTERM_BP_FAT GO:0009206~purine ribonucleoside triphosphate biosynthetic process 4 4.705882352941177 0.017701682209394384 ATP2B4, ATP6V1E1, ATP6V1B2, TGFB1 77 98 13528 7.17095149748211 0.9999999948926581 0.506944158512338 24.7674235389329 GOTERM_BP_FAT GO:0009145~purine nucleoside triphosphate biosynthetic process 4 4.705882352941177 0.018182556655814083 ATP2B4, ATP6V1E1, ATP6V1B2, TGFB1 77 99 13528 7.0985176439721895 0.9999999969740274 0.5036989681464061 25.35212429564012 GOTERM_BP_FAT GO:0009201~ribonucleoside triphosphate biosynthetic process 4 4.705882352941177 0.018182556655814083 ATP2B4, ATP6V1E1, ATP6V1B2, TGFB1 77 99 13528 7.0985176439721895 0.9999999969740274 0.5036989681464061 25.35212429564012 GOTERM_MF_FAT GO:0019829~cation-transporting ATPase activity 3 3.5294117647058822 0.018735665294552725 ATP2B4, ATP6V1E1, ATP6V1B2 77 36 12983 14.050865800865802 0.990464148470949 0.6875073045301197 21.735778929507777 GOTERM_BP_FAT GO:0009142~nucleoside triphosphate biosynthetic process 4 4.705882352941177 0.01966868869774284 ATP2B4, ATP6V1E1, ATP6V1B2, TGFB1 77 102 13528 6.889737713267126 0.9999999994007579 0.5072952558959791 27.13232314259151 GOTERM_BP_FAT GO:0009165~nucleotide biosynthetic process 5 5.88235294117647 0.02060817239112857 ATP2B4, ATP6V1E1, ATP6V1B2, NT5E, TGFB1 77 186 13528 4.722804077642786 0.9999999997849831 0.512309519906493 28.23709469741025 GOTERM_BP_FAT GO:0034654~nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process 5 5.88235294117647 0.023231963273736875 ATP2B4, ATP6V1E1, ATP6V1B2, NT5E, TGFB1 77 193 13528 4.551510665500302 0.9999999999877807 0.5330133010123855 31.239937295848698 GOTERM_BP_FAT GO:0034404~nucleobase, nucleoside and nucleotide biosynthetic process 5 5.88235294117647 0.023231963273736875 ATP2B4, ATP6V1E1, ATP6V1B2, NT5E, TGFB1 77 193 13528 4.551510665500302 0.9999999999877807 0.5330133010123855 31.239937295848698 GOTERM_MF_FAT GO:0042626~ATPase activity, coupled to transmembrane movement of substances 4 4.705882352941177 0.025999234733410235 ABCF1, ATP2B4, ATP6V1E1, ATP6V1B2 77 109 12983 6.187537233408793 0.9984668405192975 0.6037757540657449 28.919329079914313 GOTERM_MF_FAT GO:0043492~ATPase activity, coupled to movement of substances 4 4.705882352941177 0.02661830367347539 ABCF1, ATP2B4, ATP6V1E1, ATP6V1B2 77 110 12983 6.131286894923259 0.9986888235107969 0.5637779200727848 29.502531214237294 GOTERM_MF_FAT GO:0016820~hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 4 4.705882352941177 0.027245261234984185 ABCF1, ATP2B4, ATP6V1E1, ATP6V1B2 77 111 12983 6.076050076050077 0.9988810121654544 0.530006656350262 30.088661668862436 GOTERM_BP_FAT GO:0009152~purine ribonucleotide biosynthetic process 4 4.705882352941177 0.028081059726568717 ATP2B4, ATP6V1E1, ATP6V1B2, TGFB1 77 117 13528 6.006438006438007 0.9999999999999403 0.5916109599868893 36.4820462108431 GOTERM_BP_FAT GO:0009260~ribonucleotide biosynthetic process 4 4.705882352941177 0.03256570321697036 ATP2B4, ATP6V1E1, ATP6V1B2, TGFB1 77 124 13528 5.667364893171346 0.9999999999999996 0.6258568267088915 40.99458014707881 GOTERM_MF_FAT GO:0015399~primary active transmembrane transporter activity 4 4.705882352941177 0.03466027036320912 ABCF1, ATP2B4, ATP6V1E1, ATP6V1B2 77 122 12983 5.52820949542261 0.9998296569627272 0.5801129904486163 36.68801107519138 GOTERM_MF_FAT GO:0015405~P-P-bond-hydrolysis-driven transmembrane transporter activity 4 4.705882352941177 0.03466027036320912 ABCF1, ATP2B4, ATP6V1E1, ATP6V1B2 77 122 12983 5.52820949542261 0.9998296569627272 0.5801129904486163 36.68801107519138 GOTERM_BP_FAT GO:0044271~nitrogen compound biosynthetic process 6 7.0588235294117645 0.03589392532443826 ATP2B4, ATP6V1E1, ASNS, ATP6V1B2, NT5E, TGFB1 77 325 13528 3.2434765234765233 1.0 0.6521948606124248 44.14731689579086 GOTERM_MF_FAT GO:0042625~ATPase activity, coupled to transmembrane movement of ions 3 3.5294117647058822 0.06973369560229391 ATP2B4, ATP6V1E1, ATP6V1B2 77 74 12983 6.835556335556336 0.9999999810594121 0.7727784832711186 60.80653713969836 GOTERM_MF_FAT GO:0042623~ATPase activity, coupled 5 5.88235294117647 0.07512915295939337 ABCF1, ATP2B4, ATP6V1E1, XRCC6, ATP6V1B2 77 272 12983 3.0994556913674556 0.9999999954715644 0.7464892970459539 63.652113512456346 KEGG_PATHWAY hsa05110:Vibrio cholerae infection 3 3.5294117647058822 0.1223178983182037 SLC12A2, ATP6V1E1, ATP6V1B2 56 56 5085 4.864477040816326 0.9998597404451184 0.8911738878629056 73.87422939814307 GOTERM_MF_FAT GO:0016887~ATPase activity 5 5.88235294117647 0.13189948961517806 ABCF1, ATP2B4, ATP6V1E1, XRCC6, ATP6V1B2 77 334 12983 2.5241076288980477 0.9999999999999992 0.8708566844771184 84.00475387598985 GOTERM_MF_FAT GO:0022890~inorganic cation transmembrane transporter activity 3 3.5294117647058822 0.22124883402464984 ATP2B4, ATP6V1E1, ATP6V1B2 77 151 12983 3.349875290272641 1.0 0.9465665200942461 96.08487393032681 SP_PIR_KEYWORDS ion transport 4 4.705882352941177 0.4646850817531111 ATP2B4, SLC12A2, ATP6V1E1, ATP6V1B2 85 578 19235 1.5660492570730713 1.0 0.9862267789019667 99.95820284917383 GOTERM_BP_FAT GO:0015672~monovalent inorganic cation transport 3 3.5294117647058822 0.5365917255359696 SLC12A2, ATP6V1E1, ATP6V1B2 77 318 13528 1.6574369027199216 1.0 0.9988167511022371 99.99952417256168 GOTERM_BP_FAT GO:0006812~cation transport 4 4.705882352941177 0.6059486369409933 ATP2B4, SLC12A2, ATP6V1E1, ATP6V1B2 77 553 13528 1.2708015311993612 1.0 0.9995277196857429 99.99996406499375 GOTERM_BP_FAT GO:0055085~transmembrane transport 4 4.705882352941177 0.6254627564553412 SLC12A2, SLC25A6, ATP6V1E1, ATP6V1B2 77 569 13528 1.2350672174925252 1.0 0.9996041700071333 99.99998400268113 GOTERM_BP_FAT GO:0006811~ion transport 4 4.705882352941177 0.8136170651620368 ATP2B4, SLC12A2, ATP6V1E1, ATP6V1B2 77 768 13528 0.9150432900432901 1.0 0.9999920130641476 99.99999999976308 GOTERM_BP_FAT GO:0016310~phosphorylation 3 3.5294117647058822 0.9442733958591293 ATP6V1E1, ATP6V1B2, TGFB1 77 800 13528 0.6588311688311689 1.0 0.9999999974454556 100.0 GOTERM_BP_FAT GO:0006793~phosphorus metabolic process 3 3.5294117647058822 0.97657719417461 ATP6V1E1, ATP6V1B2, TGFB1 77 973 13528 0.5416905807450514 1.0 0.9999999999906832 100.0 GOTERM_BP_FAT GO:0006796~phosphate metabolic process 3 3.5294117647058822 0.97657719417461 ATP6V1E1, ATP6V1B2, TGFB1 77 973 13528 0.5416905807450514 1.0 0.9999999999906832 100.0 Annotation Cluster 7 Enrichment Score: 1.3676458506617257 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042254~ribosome biogenesis 5 5.88235294117647 0.004900300765961385 SBDS, RPL14, RPS15, RPL24, RPL7A 77 122 13528 7.200340642963592 0.9947592912071853 0.3127744655112328 7.528859758683404 GOTERM_BP_FAT GO:0034660~ncRNA metabolic process 6 7.0588235294117645 0.00945002157316431 SBDS, RPL14, RPS15, GARS, SSB, FARSA 77 230 13528 4.58317334839074 0.9999609281511401 0.39800456479291413 14.040431197447944 GOTERM_BP_FAT GO:0022613~ribonucleoprotein complex biogenesis 5 5.88235294117647 0.018512076670171396 SBDS, RPL14, RPS15, RPL24, RPL7A 77 180 13528 4.880230880230879 0.9999999978864016 0.4978160322326036 25.750329279501404 GOTERM_BP_FAT GO:0034470~ncRNA processing 4 4.705882352941177 0.08802755117167961 SBDS, RPL14, RPS15, SSB 77 187 13528 3.7580387526911596 1.0 0.8277815857328785 76.96720683506926 GOTERM_BP_FAT GO:0006364~rRNA processing 3 3.5294117647058822 0.09441947349504626 SBDS, RPL14, RPS15 77 92 13528 5.728966685488425 1.0 0.8392609368626026 79.40917435544938 GOTERM_BP_FAT GO:0016072~rRNA metabolic process 3 3.5294117647058822 0.10142036062384836 SBDS, RPL14, RPS15 77 96 13528 5.49025974025974 1.0 0.846503671997359 81.80433130784384 GOTERM_BP_FAT GO:0006396~RNA processing 5 5.88235294117647 0.36945625467385756 HNRNPA3, SBDS, RPL14, RPS15, SSB 77 547 13528 1.6059260666207649 1.0 0.9900224470547305 99.93563468741236 Annotation Cluster 8 Enrichment Score: 1.2898675243270499 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0000267~cell fraction 16 18.823529411764707 0.0023361050234607626 COPA, STX4, PLXNA1, SLC12A2, XRCC6, GARS, ADH5, MME, SNAPIN, ASNS, CTTN, FBLN1, RAB14, RPL7A, FARSA, NT5E 80 1083 12782 2.3604801477377655 0.38664852369509317 0.03690316645672542 2.909447412516175 GOTERM_CC_FAT GO:0005624~membrane fraction 10 11.76470588235294 0.061138302186187723 COPA, STX4, SLC12A2, PLXNA1, XRCC6, RAB14, MME, SNAPIN, RPL7A, NT5E 80 809 12782 1.9749690976514216 0.9999981218124864 0.32937932592216623 54.90632776598441 GOTERM_CC_FAT GO:0005626~insoluble fraction 10 11.76470588235294 0.07332570175308475 COPA, STX4, SLC12A2, PLXNA1, XRCC6, RAB14, MME, SNAPIN, RPL7A, NT5E 80 839 12782 1.9043504171632897 0.9999998776038872 0.36538892579647286 61.76340945111058 GOTERM_BP_FAT GO:0007267~cell-cell signaling 4 4.705882352941177 0.6614057058428611 STX4, RAB14, MME, SNAPIN 77 600 13528 1.1712554112554112 1.0 0.9997726362451895 99.99999679453725 Annotation Cluster 9 Enrichment Score: 1.1555032901540423 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS extracellular matrix 8 9.411764705882353 8.863902025734687E-5 FBLN1, TNXB, LGALS1, ELN, CCDC80, NID2, TIMP3, MMP2 85 241 19235 7.511837930192824 0.01687543358209509 0.002832555089836042 0.11030089146000233 SMART SM00181:EGF 3 3.5294117647058822 0.18110591026731462 FBLN1, TNXB, NID2 36 201 9079 3.7640961857379764 0.9999316196436694 0.9999316196436694 85.1446742082013 INTERPRO IPR000742:EGF-like, type 3 3 3.5294117647058822 0.24750831721973413 FBLN1, TNXB, NID2 83 194 16659 3.103775928456092 1.0 0.9999999982954059 97.69065728438751 INTERPRO IPR006210:EGF-like 3 3.5294117647058822 0.2602826703640294 FBLN1, TNXB, NID2 83 201 16659 2.995684229455134 1.0 0.9999999634458193 98.159427263795 SP_PIR_KEYWORDS egf-like domain 3 3.5294117647058822 0.265865486724319 FBLN1, TNXB, NID2 85 230 19235 2.9516624040920716 1.0 0.9407339658586827 97.86750947074015 INTERPRO IPR013032:EGF-like region, conserved site 3 3.5294117647058822 0.424351434115386 FBLN1, TNXB, NID2 83 293 16659 2.0550598297627367 1.0 0.9999999969409353 99.93365980415369 Annotation Cluster 10 Enrichment Score: 1.1418317040629016 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051493~regulation of cytoskeleton organization 4 4.705882352941177 0.041070874159401104 SBDS, PFN2, ELN, NEXN 77 136 13528 5.167303284950345 1.0 0.6926552761199273 48.7392099775947 GOTERM_MF_FAT GO:0008092~cytoskeletal protein binding 7 8.235294117647058 0.07444068439508265 STX4, SBDS, PFN2, EZR, TNNT1, MYPN, NEXN 77 504 12983 2.341810966810967 0.9999999945619018 0.7686523154446752 63.299942462193556 GOTERM_BP_FAT GO:0033043~regulation of organelle organization 4 4.705882352941177 0.12278931708241304 SBDS, PFN2, ELN, NEXN 77 217 13528 3.2384942246693402 1.0 0.8763454281684967 87.60019770540981 Annotation Cluster 11 Enrichment Score: 1.1109975549356763 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS extracellular matrix 8 9.411764705882353 8.863902025734687E-5 FBLN1, TNXB, LGALS1, ELN, CCDC80, NID2, TIMP3, MMP2 85 241 19235 7.511837930192824 0.01687543358209509 0.002832555089836042 0.11030089146000233 GOTERM_CC_FAT GO:0031012~extracellular matrix 10 11.76470588235294 2.670639166410995E-4 STX4, FBLN1, TNXB, LGALS1, ELN, CCDC80, NID2, TIMP3, MMP2, TGFB1 80 345 12782 4.631159420289855 0.05429425789289555 0.005566828780228517 0.336625743063379 GOTERM_CC_FAT GO:0005578~proteinaceous extracellular matrix 9 10.588235294117647 7.875659292793472E-4 FBLN1, TNXB, LGALS1, ELN, CCDC80, NID2, TIMP3, MMP2, TGFB1 80 320 12782 4.4936718749999995 0.1518231627614237 0.014858160045091773 0.9897057038069312 GOTERM_CC_FAT GO:0044420~extracellular matrix part 4 4.705882352941177 0.035770155806964694 TNXB, CCDC80, NID2, TIMP3 80 117 12782 5.4623931623931625 0.9995059862997208 0.23806267343362353 36.8619288485655 GOTERM_CC_FAT GO:0044421~extracellular region part 11 12.941176470588237 0.07084968003470532 COPA, STX4, FBLN1, TNXB, LGALS1, ELN, CCDC80, NID2, TIMP3, MMP2, TGFB1 80 960 12782 1.8307552083333334 0.9999997862185668 0.36346447501570234 60.45341795498547 GOTERM_CC_FAT GO:0005604~basement membrane 3 3.5294117647058822 0.08386081665459776 CCDC80, NID2, TIMP3 80 78 12782 6.145192307692308 0.9999999887812416 0.3902755043919274 66.90279211561042 SP_PIR_KEYWORDS Secreted 12 14.117647058823529 0.11682597332249112 COPA, FBLN1, TNXB, LGALS1, ELN, CCDC80, ANTXR2, NID2, TIMP3, MMP2, TGFB1, B2M 85 1689 19235 1.6077734823947343 0.9999999999562591 0.8180033544239971 78.70545325558368 GOTERM_CC_FAT GO:0005615~extracellular space 6 7.0588235294117645 0.4180479565313776 COPA, FBLN1, TNXB, LGALS1, MMP2, TGFB1 80 685 12782 1.3994890510948905 1.0 0.8912326580776858 99.89238480397418 SP_PIR_KEYWORDS disulfide bond 14 16.470588235294116 0.5186036387597461 FBLN1, TNXB, TXNDC17, MYPN, ELN, MME, ANTXR2, PTGFRN, NID2, TIMP3, NT5E, MMP2, TGFB1, B2M 85 2924 19235 1.0834875673935784 1.0 0.9907099523698576 99.98885414287332 UP_SEQ_FEATURE disulfide bond 13 15.294117647058824 0.5948457554112022 FBLN1, TNXB, TXNDC17, MYPN, ELN, MME, ANTXR2, PTGFRN, NID2, TIMP3, MMP2, TGFB1, B2M 85 2819 19113 1.0369509421363439 1.0 1.0 99.9995537001032 GOTERM_CC_FAT GO:0005576~extracellular region 13 15.294117647058824 0.5998699576627416 COPA, STX4, TNXB, LGALS1, ELN, CCDC80, NID2, MMP2, TIMP3, TGFB1, B2M, FBLN1, ANTXR2 80 2010 12782 1.0333706467661692 1.0 0.9543928490728586 99.99904921592204 SP_PIR_KEYWORDS signal 13 15.294117647058824 0.780358248609833 TNXB, PLXNA1, ELN, CCDC80, NID2, MMP2, TIMP3, TGFB1, B2M, FBLN1, ANTXR2, PTGFRN, NT5E 85 3250 19235 0.9051764705882354 1.0 0.9995280153159802 99.99999936283162 UP_SEQ_FEATURE signal peptide 13 15.294117647058824 0.7879220884878273 TNXB, PLXNA1, ELN, CCDC80, NID2, MMP2, TIMP3, TGFB1, B2M, FBLN1, ANTXR2, PTGFRN, NT5E 85 3250 19113 0.8994352941176471 1.0 1.0 99.99999993449275 SP_PIR_KEYWORDS glycoprotein 12 14.117647058823529 0.9895546660394724 FBLN1, TNXB, SLC12A2, PLXNA1, MME, ANTXR2, NID2, PTGFRN, NT5E, MMP2, TGFB1, B2M 85 4318 19235 0.6288859221317058 1.0 0.9999999946153922 100.0 UP_SEQ_FEATURE glycosylation site:N-linked (GlcNAc...) 11 12.941176470588237 0.9926865526509971 FBLN1, TNXB, SLC12A2, PLXNA1, MME, ANTXR2, NID2, PTGFRN, NT5E, MMP2, TGFB1 85 4129 19113 0.5990426395794454 1.0 1.0 100.0 Annotation Cluster 12 Enrichment Score: 0.9380931101063572 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0005504~fatty acid binding 3 3.5294117647058822 0.020750350844580583 ADH5, DBI, HADHB 77 38 12983 13.311346548188652 0.9942484823503056 0.5767174065275458 23.79260742024526 GOTERM_MF_FAT GO:0033293~monocarboxylic acid binding 3 3.5294117647058822 0.03978750339216882 ADH5, DBI, HADHB 77 54 12983 9.367243867243866 0.9999540411635488 0.5966612840448768 40.90967536731087 GOTERM_MF_FAT GO:0048037~cofactor binding 4 4.705882352941177 0.178861167308809 ADH5, ASNS, DBI, HADHB 77 249 12983 2.7086006363114796 1.0 0.9220313396478002 92.21943410980329 GOTERM_MF_FAT GO:0031406~carboxylic acid binding 3 3.5294117647058822 0.20621763742743918 ADH5, DBI, HADHB 77 144 12983 3.5127164502164505 1.0 0.9416114390043316 94.98428912624257 GOTERM_MF_FAT GO:0008289~lipid binding 5 5.88235294117647 0.26975050808284873 PFN2, ADH5, SNX3, DBI, HADHB 77 450 12983 1.8734487734487735 1.0 0.9702586627530341 98.29838139074847 GOTERM_MF_FAT GO:0050662~coenzyme binding 3 3.5294117647058822 0.2863288226362619 ADH5, DBI, HADHB 77 181 12983 2.7946473416086675 1.0 0.9728938866663821 98.73633826236787 Annotation Cluster 13 Enrichment Score: 0.8449465092862399 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032269~negative regulation of cellular protein metabolic process 5 5.88235294117647 0.018512076670171396 PSMB5, PSMA5, PSMD3, TIMP3, TGFB1 77 180 13528 4.880230880230879 0.9999999978864016 0.4978160322326036 25.750329279501404 GOTERM_BP_FAT GO:0051248~negative regulation of protein metabolic process 5 5.88235294117647 0.02097116769755242 PSMB5, PSMA5, PSMD3, TIMP3, TGFB1 77 187 13528 4.697548440863948 0.9999999998553327 0.5073805353468461 28.65973340242497 SP_PIR_KEYWORDS proteasome 3 3.5294117647058822 0.024919163973600493 PSMB5, PSMA5, PSMD3 85 56 19235 12.122899159663865 0.9921331796028019 0.35626218529656073 26.96111595327224 GOTERM_BP_FAT GO:0031400~negative regulation of protein modification process 4 4.705882352941177 0.029326243699366396 PSMB5, PSMA5, PSMD3, TGFB1 77 119 13528 5.905489468514679 0.9999999999999848 0.5971148310607038 37.76637556928654 GOTERM_BP_FAT GO:0051436~negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle 3 3.5294117647058822 0.051618510045633136 PSMB5, PSMA5, PSMD3 77 65 13528 8.10869130869131 1.0 0.7660624050881298 57.02191906577274 GOTERM_BP_FAT GO:0031145~anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process 3 3.5294117647058822 0.051618510045633136 PSMB5, PSMA5, PSMD3 77 65 13528 8.10869130869131 1.0 0.7660624050881298 57.02191906577274 GOTERM_BP_FAT GO:0007346~regulation of mitotic cell cycle 4 4.705882352941177 0.05397749138174241 SBDS, ASNS, RPL24, TGFB1 77 152 13528 4.623376623376624 1.0 0.7646712956111636 58.69403638463451 GOTERM_BP_FAT GO:0051352~negative regulation of ligase activity 3 3.5294117647058822 0.05448049844918687 PSMB5, PSMA5, PSMD3 77 67 13528 7.866640821864703 1.0 0.7596987329375913 59.04260491970725 GOTERM_BP_FAT GO:0051444~negative regulation of ubiquitin-protein ligase activity 3 3.5294117647058822 0.05448049844918687 PSMB5, PSMA5, PSMD3 77 67 13528 7.866640821864703 1.0 0.7596987329375913 59.04260491970725 GOTERM_CC_FAT GO:0000502~proteasome complex 3 3.5294117647058822 0.05460672206568509 PSMB5, PSMA5, PSMD3 80 61 12782 7.857786885245901 0.9999920013887535 0.31517261953072195 50.78178538128741 GOTERM_BP_FAT GO:0051437~positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle 3 3.5294117647058822 0.05593223516853419 PSMB5, PSMA5, PSMD3 77 68 13528 7.750954927425516 1.0 0.7609068395713038 60.033217481742795 GOTERM_BP_FAT GO:0051443~positive regulation of ubiquitin-protein ligase activity 3 3.5294117647058822 0.0588762167580083 PSMB5, PSMA5, PSMD3 77 70 13528 7.529499072356216 1.0 0.7634277100659569 61.97353837220603 GOTERM_BP_FAT GO:0051439~regulation of ubiquitin-protein ligase activity during mitotic cell cycle 3 3.5294117647058822 0.06036807598996543 PSMB5, PSMA5, PSMD3 77 71 13528 7.423449789646972 1.0 0.7647324991614304 62.92274354902293 GOTERM_BP_FAT GO:0051351~positive regulation of ligase activity 3 3.5294117647058822 0.0633905798916185 PSMB5, PSMA5, PSMD3 77 73 13528 7.220067603629247 1.0 0.7745201965149363 64.77816366287159 GOTERM_BP_FAT GO:0031397~negative regulation of protein ubiquitination 3 3.5294117647058822 0.06492084898734618 PSMB5, PSMA5, PSMD3 77 74 13528 7.122499122499122 1.0 0.7757311310265999 65.68401527847618 GOTERM_BP_FAT GO:0051438~regulation of ubiquitin-protein ligase activity 3 3.5294117647058822 0.07116440143343931 PSMB5, PSMA5, PSMD3 77 78 13528 6.757242757242757 1.0 0.800223903749284 69.15846466737482 GOTERM_BP_FAT GO:0051340~regulation of ligase activity 3 3.5294117647058822 0.07597061296486418 PSMB5, PSMA5, PSMD3 77 81 13528 6.506974506974507 1.0 0.8153445847507333 71.60541804198326 GOTERM_BP_FAT GO:0031398~positive regulation of protein ubiquitination 3 3.5294117647058822 0.08087743942686296 PSMB5, PSMA5, PSMD3 77 84 13528 6.274582560296846 1.0 0.8233790696146036 73.91503482637754 GOTERM_BP_FAT GO:0031401~positive regulation of protein modification process 4 4.705882352941177 0.08802755117167961 PSMB5, PSMA5, PSMD3, TGFB1 77 187 13528 3.7580387526911596 1.0 0.8277815857328785 76.96720683506926 KEGG_PATHWAY hsa03050:Proteasome 3 3.5294117647058822 0.09120688165535579 PSMB5, PSMA5, PSMD3 56 47 5085 5.7959726443769 0.9985016198038396 0.8855697953082583 62.614806346702665 GOTERM_BP_FAT GO:0022402~cell cycle process 7 8.235294117647058 0.09749426879123961 PSMB5, SBDS, GSPT1, PSMA5, PSMD3, RPL24, TGFB1 77 565 13528 2.176669348350764 1.0 0.8441115869151516 80.49538105119625 GOTERM_BP_FAT GO:0031396~regulation of protein ubiquitination 3 3.5294117647058822 0.10856121893959553 PSMB5, PSMA5, PSMD3 77 100 13528 5.270649350649351 1.0 0.8621263506788458 83.97656104582938 GOTERM_BP_FAT GO:0043161~proteasomal ubiquitin-dependent protein catabolic process 3 3.5294117647058822 0.11218115174276036 PSMB5, PSMA5, PSMD3 77 102 13528 5.167303284950344 1.0 0.8587024968714548 84.98249917067444 GOTERM_BP_FAT GO:0010498~proteasomal protein catabolic process 3 3.5294117647058822 0.11218115174276036 PSMB5, PSMA5, PSMD3 77 102 13528 5.167303284950344 1.0 0.8587024968714548 84.98249917067444 GOTERM_BP_FAT GO:0032270~positive regulation of cellular protein metabolic process 4 4.705882352941177 0.14309629414196456 PSMB5, PSMA5, PSMD3, TGFB1 77 233 13528 3.016108355164149 1.0 0.8990219889372586 91.46240953473857 GOTERM_BP_FAT GO:0000278~mitotic cell cycle 5 5.88235294117647 0.15441628036585403 PSMB5, GSPT1, PSMA5, PSMD3, RPL24 77 370 13528 2.3741663741663737 1.0 0.9055068666709805 93.09267865450173 GOTERM_BP_FAT GO:0051247~positive regulation of protein metabolic process 4 4.705882352941177 0.15632528651693633 PSMB5, PSMA5, PSMD3, TGFB1 77 243 13528 2.8919886697664476 1.0 0.9055766618888 93.3370107423748 GOTERM_BP_FAT GO:0043086~negative regulation of catalytic activity 4 4.705882352941177 0.20385421781229804 PSMB5, GPX1, PSMA5, PSMD3 77 277 13528 2.537015331239158 1.0 0.946932040995953 97.35509003243486 GOTERM_BP_FAT GO:0031399~regulation of protein modification process 4 4.705882352941177 0.2302709958771691 PSMB5, PSMA5, PSMD3, TGFB1 77 295 13528 2.382214395773718 1.0 0.9583837236498463 98.45509639544856 GOTERM_BP_FAT GO:0007049~cell cycle 7 8.235294117647058 0.26966999356809807 PSMB5, SBDS, GSPT1, PSMA5, PSMD3, RPL24, TGFB1 77 776 13528 1.584817244611059 1.0 0.9708773282402791 99.33118359582157 GOTERM_BP_FAT GO:0032268~regulation of cellular protein metabolic process 5 5.88235294117647 0.2761587790278638 PSMB5, PSMA5, PSMD3, TIMP3, TGFB1 77 474 13528 1.8532522329990682 1.0 0.9726429167937887 99.41983811850054 GOTERM_BP_FAT GO:0051726~regulation of cell cycle 4 4.705882352941177 0.2847591021452618 SBDS, ASNS, RPL24, TGFB1 77 331 13528 2.123121591399537 1.0 0.9721967534270317 99.52044770346706 GOTERM_BP_FAT GO:0044092~negative regulation of molecular function 4 4.705882352941177 0.28936488514193515 PSMB5, GPX1, PSMA5, PSMD3 77 334 13528 2.1040516369857687 1.0 0.9730967475872158 99.56735649713501 GOTERM_BP_FAT GO:0043085~positive regulation of catalytic activity 5 5.88235294117647 0.33469921351493837 PSMB5, GSPT1, PSMA5, PSMD3, TGFB1 77 520 13528 1.6893106893106893 1.0 0.9835882989268631 99.84865776226928 GOTERM_BP_FAT GO:0006511~ubiquitin-dependent protein catabolic process 3 3.5294117647058822 0.39559303768388143 PSMB5, PSMA5, PSMD3 77 242 13528 2.177954277127831 1.0 0.9921645348294527 99.9672137184203 GOTERM_BP_FAT GO:0044093~positive regulation of molecular function 5 5.88235294117647 0.4194941809835713 PSMB5, GSPT1, PSMA5, PSMD3, TGFB1 77 586 13528 1.499047028057267 1.0 0.9941713440765839 99.98276220690492 GOTERM_BP_FAT GO:0009057~macromolecule catabolic process 6 7.0588235294117645 0.44882095476428535 PSMB5, GSPT1, PSMA5, UBA2, PSMD3, TGFB1 77 781 13528 1.3497181435721768 1.0 0.9960631677712216 99.9924535215842 GOTERM_BP_FAT GO:0044265~cellular macromolecule catabolic process 5 5.88235294117647 0.5869122446116397 PSMB5, GSPT1, PSMA5, UBA2, PSMD3 77 725 13528 1.2116435288849081 1.0 0.9994473447462856 99.99992379239823 GOTERM_BP_FAT GO:0010605~negative regulation of macromolecule metabolic process 5 5.88235294117647 0.596824068036635 PSMB5, PSMA5, PSMD3, TIMP3, TGFB1 77 734 13528 1.196786864361796 1.0 0.9995221179965775 99.99994824762103 GOTERM_BP_FAT GO:0043632~modification-dependent macromolecule catabolic process 4 4.705882352941177 0.631427477572517 PSMB5, PSMA5, UBA2, PSMD3 77 574 13528 1.2243087922530433 1.0 0.9996305939612224 99.999987613343 GOTERM_BP_FAT GO:0019941~modification-dependent protein catabolic process 4 4.705882352941177 0.631427477572517 PSMB5, PSMA5, UBA2, PSMD3 77 574 13528 1.2243087922530433 1.0 0.9996305939612224 99.999987613343 GOTERM_BP_FAT GO:0051603~proteolysis involved in cellular protein catabolic process 4 4.705882352941177 0.6614057058428611 PSMB5, PSMA5, UBA2, PSMD3 77 600 13528 1.1712554112554112 1.0 0.9997726362451895 99.99999679453725 GOTERM_BP_FAT GO:0044257~cellular protein catabolic process 4 4.705882352941177 0.6647519390682268 PSMB5, PSMA5, UBA2, PSMD3 77 603 13528 1.1654282699058818 1.0 0.9997624076340189 99.99999726371445 GOTERM_BP_FAT GO:0030163~protein catabolic process 4 4.705882352941177 0.6854004473931883 PSMB5, PSMA5, UBA2, PSMD3 77 622 13528 1.1298283709859274 1.0 0.9998240138911244 99.99999900630905 GOTERM_BP_FAT GO:0006508~proteolysis 6 7.0588235294117645 0.7157208004494938 PSMB5, PSMA5, UBA2, PSMD3, MME, MMP2 77 1054 13528 1.000123216442002 1.0 0.9999119324457673 99.99999980232779 GOTERM_BP_FAT GO:0010604~positive regulation of macromolecule metabolic process 5 5.88235294117647 0.7176919638463048 PSMB5, PSMA5, XRCC6, PSMD3, TGFB1 77 857 13528 1.0250193214020518 1.0 0.9999107713247828 99.99999982307247 Annotation Cluster 14 Enrichment Score: 0.8275229855945322 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0030017~sarcomere 3 3.5294117647058822 0.12286090843994285 TNNT1, MYPN, MMP2 80 98 12782 4.891071428571428 0.9999999999987372 0.4958813803008466 80.88909654934857 GOTERM_CC_FAT GO:0030016~myofibril 3 3.5294117647058822 0.15014268814842052 TNNT1, MYPN, MMP2 80 111 12782 4.318243243243243 0.9999999999999983 0.5549464043797121 87.17535504116792 GOTERM_CC_FAT GO:0044449~contractile fiber part 3 3.5294117647058822 0.15444391300112048 TNNT1, MYPN, MMP2 80 113 12782 4.241814159292035 0.9999999999999994 0.5575356595082166 87.97108147953536 GOTERM_CC_FAT GO:0043292~contractile fiber 3 3.5294117647058822 0.1718776281069186 TNNT1, MYPN, MMP2 80 121 12782 3.9613636363636364 1.0 0.5917286005674893 90.75294467819431 Annotation Cluster 15 Enrichment Score: 0.7196275185696064 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0033273~response to vitamin 3 3.5294117647058822 0.05304252437522162 SCAMP3, TIMP3, TGFB1 77 66 13528 7.985832349468713 1.0 0.7669591828482846 58.038734095867405 GOTERM_BP_FAT GO:0031667~response to nutrient levels 4 4.705882352941177 0.09909216083764294 SCAMP3, ASNS, TIMP3, TGFB1 77 197 13528 3.5672753642296793 1.0 0.8442044007916936 81.03841740127115 GOTERM_BP_FAT GO:0009991~response to extracellular stimulus 4 4.705882352941177 0.1265108847604809 SCAMP3, ASNS, TIMP3, TGFB1 77 220 13528 3.1943329397874853 1.0 0.8807294268234167 88.41238931151553 GOTERM_BP_FAT GO:0007584~response to nutrient 3 3.5294117647058822 0.18573848406839896 SCAMP3, TIMP3, TGFB1 77 140 13528 3.764749536178108 1.0 0.9335792247437302 96.21463754992706 GOTERM_BP_FAT GO:0010033~response to organic substance 5 5.88235294117647 0.5824637627117754 ADH5, ASNS, TIMP3, TGFB1, B2M 77 721 13528 1.218365545688708 1.0 0.9994296038717996 99.99990960984421 GOTERM_BP_FAT GO:0009719~response to endogenous stimulus 3 3.5294117647058822 0.668763718595691 ASNS, TIMP3, TGFB1 77 405 13528 1.3013949013949013 1.0 0.9997699106250909 99.99999774133288 Annotation Cluster 16 Enrichment Score: 0.679135559494189 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030036~actin cytoskeleton organization 4 4.705882352941177 0.13407536422317998 PFN2, EZR, TNXB, ELN 77 226 13528 3.109527640501092 1.0 0.8925034503703481 89.91201154599634 GOTERM_BP_FAT GO:0030029~actin filament-based process 4 4.705882352941177 0.15364875670224476 PFN2, EZR, TNXB, ELN 77 241 13528 2.9159885757396133 1.0 0.9072412104747132 92.99209740829436 GOTERM_BP_FAT GO:0007010~cytoskeleton organization 4 4.705882352941177 0.4453641813314486 PFN2, EZR, TNXB, ELN 77 436 13528 1.6118193732872632 1.0 0.9960233918408978 99.99166302093599 Annotation Cluster 17 Enrichment Score: 0.6508577714095625 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001503~ossification 3 3.5294117647058822 0.13642771046663144 SBDS, MMP2, TGFB1 77 115 13528 4.58317334839074 1.0 0.893539103476661 90.33993323771293 GOTERM_BP_FAT GO:0060348~bone development 3 3.5294117647058822 0.15188073497103927 SBDS, MMP2, TGFB1 77 123 13528 4.285080772885651 1.0 0.910394427521938 92.75515735112263 GOTERM_BP_FAT GO:0001501~skeletal system development 3 3.5294117647058822 0.5382963125826803 SBDS, MMP2, TGFB1 77 319 13528 1.6522411757521474 1.0 0.9987895057985436 99.99955130836786 Annotation Cluster 18 Enrichment Score: 0.650424440201316 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR013783:Immunoglobulin-like fold 6 7.0588235294117645 0.13661870478521254 GBE1, MYPN, MYBPH, PTGFRN, NEXN, B2M 83 553 16659 2.1776945031482167 1.0 1.0 85.72412664258373 INTERPRO IPR013098:Immunoglobulin I-set 3 3.5294117647058822 0.14788824980733373 MYPN, MYBPH, NEXN 83 138 16659 4.363279203771608 1.0 0.999999999864945 88.00529004652219 SP_PIR_KEYWORDS Immunoglobulin domain 5 5.88235294117647 0.14988679627687124 MYPN, MYBPH, PTGFRN, NEXN, B2M 85 470 19235 2.40738423028786 0.9999999999999712 0.8230901055308709 86.75733573333781 INTERPRO IPR007110:Immunoglobulin-like 5 5.88235294117647 0.23313046319284936 MYPN, MYBPH, PTGFRN, NEXN, B2M 83 501 16659 2.003102229276387 1.0 0.9999999999877829 97.03236081648237 SMART SM00409:IG 3 3.5294117647058822 0.36522924268461404 MYBPH, PTGFRN, NEXN 36 330 9079 2.2926767676767676 0.9999999996645624 0.9993051827648212 98.69304932082034 INTERPRO IPR003599:Immunoglobulin subtype 3 3.5294117647058822 0.4853796671722468 MYBPH, PTGFRN, NEXN 83 330 16659 1.824644030668127 1.0 0.9999999992132982 99.98497446041094 Annotation Cluster 19 Enrichment Score: 0.6228462019032573 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00360:RRM 3 3.5294117647058822 0.19507368621200574 HNRNPA3, EIF3G, SSB 36 211 9079 3.5857030015797786 0.9999700570899661 0.994527988483756 87.39402977526112 SP_PIR_KEYWORDS rna-binding 5 5.88235294117647 0.2103618861902536 HNRNPA3, EIF3G, RPL8, SSB, RPL12 85 540 19235 2.0953159041394334 1.0 0.908064343289047 94.71597484832859 INTERPRO IPR000504:RNA recognition motif, RNP-1 3 3.5294117647058822 0.27854590401600016 HNRNPA3, EIF3G, SSB 83 211 16659 2.8537086735567865 1.0 0.9999998056675637 98.67845319158124 INTERPRO IPR012677:Nucleotide-binding, alpha-beta plait 3 3.5294117647058822 0.2821971795742842 HNRNPA3, EIF3G, SSB 83 213 16659 2.826913286950619 1.0 0.9999985614543351 98.76438615620208 Annotation Cluster 20 Enrichment Score: 0.5770970918971664 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0031099~regeneration 3 3.5294117647058822 0.057397539160919143 GPX1, TIMP3, TGFB1 77 69 13528 7.638622247317899 1.0 0.7621512240967734 61.010283201747605 GOTERM_BP_FAT GO:0040007~growth 4 4.705882352941177 0.08375887411771027 GPX1, SBDS, TIMP3, TGFB1 77 183 13528 3.8401816762472505 1.0 0.8230158494605678 75.18799435592035 GOTERM_BP_FAT GO:0009628~response to abiotic stimulus 5 5.88235294117647 0.15231088170897258 GPX1, SLC12A2, XRCC6, TIMP3, TGFB1 77 368 13528 2.3870694522868434 1.0 0.9081011829453516 92.81348452599535 GOTERM_BP_FAT GO:0042981~regulation of apoptosis 8 9.411764705882353 0.1645887607126237 GPX1, GSPT1, ARHGEF7, LGALS1, EEF1E1, ASNS, TIMP3, TGFB1 77 804 13528 1.7481424048588228 1.0 0.9149579368576731 94.30418966946382 GOTERM_BP_FAT GO:0043067~regulation of programmed cell death 8 9.411764705882353 0.1704601068628682 GPX1, GSPT1, ARHGEF7, LGALS1, EEF1E1, ASNS, TIMP3, TGFB1 77 812 13528 1.7309193269784404 1.0 0.9202492473343966 94.9096350397667 GOTERM_BP_FAT GO:0010941~regulation of cell death 8 9.411764705882353 0.1726860918682483 GPX1, GSPT1, ARHGEF7, LGALS1, EEF1E1, ASNS, TIMP3, TGFB1 77 815 13528 1.7245478447932436 1.0 0.9205910007070773 95.1229785824901 GOTERM_BP_FAT GO:0016477~cell migration 4 4.705882352941177 0.20240846714184166 GPX1, SBDS, ARHGEF7, TGFB1 77 276 13528 2.546207415772633 1.0 0.947573174837234 97.27751239701534 GOTERM_BP_FAT GO:0043065~positive regulation of apoptosis 5 5.88235294117647 0.22218471681892682 GPX1, ARHGEF7, EEF1E1, TIMP3, TGFB1 77 430 13528 2.0428873452129266 1.0 0.9591423672097424 98.17518010462956 GOTERM_BP_FAT GO:0043068~positive regulation of programmed cell death 5 5.88235294117647 0.22577210807357442 GPX1, ARHGEF7, EEF1E1, TIMP3, TGFB1 77 433 13528 2.0287333913199963 1.0 0.9584459363905473 98.30476520344759 GOTERM_BP_FAT GO:0010942~positive regulation of cell death 5 5.88235294117647 0.22817235409225986 GPX1, ARHGEF7, EEF1E1, TIMP3, TGFB1 77 435 13528 2.019405881474847 1.0 0.9585120266266567 98.38659623105491 GOTERM_BP_FAT GO:0009967~positive regulation of signal transduction 4 4.705882352941177 0.2302709958771691 GPX1, LGALS1, EEF1E1, TGFB1 77 295 13528 2.382214395773718 1.0 0.9583837236498463 98.45509639544856 GOTERM_BP_FAT GO:0010740~positive regulation of protein kinase cascade 3 3.5294117647058822 0.24129727780132834 GPX1, LGALS1, TGFB1 77 167 13528 3.156077455478653 1.0 0.9623714383294883 98.77240451722173 GOTERM_BP_FAT GO:0048870~cell motility 4 4.705882352941177 0.2482343478519247 GPX1, SBDS, ARHGEF7, TGFB1 77 307 13528 2.289098523626211 1.0 0.9649805305484853 98.93954621431604 GOTERM_BP_FAT GO:0051674~localization of cell 4 4.705882352941177 0.2482343478519247 GPX1, SBDS, ARHGEF7, TGFB1 77 307 13528 2.289098523626211 1.0 0.9649805305484853 98.93954621431604 GOTERM_BP_FAT GO:0006917~induction of apoptosis 4 4.705882352941177 0.2679378262623645 GPX1, ARHGEF7, TIMP3, TGFB1 77 320 13528 2.1961038961038963 1.0 0.972264892207458 99.3054552554348 GOTERM_BP_FAT GO:0012502~induction of programmed cell death 4 4.705882352941177 0.26946208089821055 GPX1, ARHGEF7, TIMP3, TGFB1 77 321 13528 2.189262450944694 1.0 0.9718616204164717 99.32814328209925 GOTERM_BP_FAT GO:0006928~cell motion 5 5.88235294117647 0.27741399412400747 GPX1, SBDS, ARHGEF7, RPL24, TGFB1 77 475 13528 1.849350649350649 1.0 0.9721467730982722 99.43566282530338 GOTERM_BP_FAT GO:0010647~positive regulation of cell communication 4 4.705882352941177 0.28169247354167326 GPX1, LGALS1, EEF1E1, TGFB1 77 329 13528 2.136028105632969 1.0 0.971917046184202 99.48661558990499 GOTERM_BP_FAT GO:0042060~wound healing 3 3.5294117647058822 0.291331679159296 GPX1, TIMP3, TGFB1 77 191 13528 2.759502277826885 1.0 0.9729240195770984 99.58604679162687 GOTERM_BP_FAT GO:0008219~cell death 6 7.0588235294117645 0.3790018080874831 GPX1, GSPT1, SLC25A6, LGALS1, GARS, TGFB1 77 719 13528 1.466105521738345 1.0 0.9910468164227014 99.94952334153126 GOTERM_BP_FAT GO:0016265~death 6 7.0588235294117645 0.3846574110635038 GPX1, GSPT1, SLC25A6, LGALS1, GARS, TGFB1 77 724 13528 1.455980483604793 1.0 0.9910751604954123 99.95637063915714 GOTERM_BP_FAT GO:0010627~regulation of protein kinase cascade 3 3.5294117647058822 0.4094304493389432 GPX1, LGALS1, TGFB1 77 249 13528 2.116726646847129 1.0 0.9934406036545167 99.97733159415966 GOTERM_BP_FAT GO:0008283~cell proliferation 4 4.705882352941177 0.4453641813314486 GPX1, SBDS, ELN, TGFB1 77 436 13528 1.6118193732872632 1.0 0.9960233918408978 99.99166302093599 GOTERM_BP_FAT GO:0009611~response to wounding 4 4.705882352941177 0.5767794086871584 ABCF1, GPX1, TIMP3, TGFB1 77 530 13528 1.3259495221759374 1.0 0.9993965457646589 99.99988787674094 GOTERM_BP_FAT GO:0006915~apoptosis 4 4.705882352941177 0.6636391300719158 GPX1, GSPT1, SLC25A6, LGALS1 77 602 13528 1.1673641972645294 1.0 0.9997704762364824 99.99999711534696 GOTERM_BP_FAT GO:0012501~programmed cell death 4 4.705882352941177 0.6735606734229101 GPX1, GSPT1, SLC25A6, LGALS1 77 611 13528 1.1501689799562143 1.0 0.9997813130616183 99.99999820979319 GOTERM_BP_FAT GO:0042127~regulation of cell proliferation 4 4.705882352941177 0.8266074902119349 GPX1, EEF1E1, TGFB1, DNAJA2 77 787 13528 0.8929520289113683 1.0 0.999994779830757 99.99999999992507 Annotation Cluster 21 Enrichment Score: 0.5520527105534937 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0040007~growth 4 4.705882352941177 0.08375887411771027 GPX1, SBDS, TIMP3, TGFB1 77 183 13528 3.8401816762472505 1.0 0.8230158494605678 75.18799435592035 GOTERM_BP_FAT GO:0048589~developmental growth 3 3.5294117647058822 0.08588026277594189 GPX1, SBDS, TIMP3 77 87 13528 6.058217644424541 1.0 0.8254009802719422 76.08771179495453 GOTERM_BP_FAT GO:0009628~response to abiotic stimulus 5 5.88235294117647 0.15231088170897258 GPX1, SLC12A2, XRCC6, TIMP3, TGFB1 77 368 13528 2.3870694522868434 1.0 0.9081011829453516 92.81348452599535 GOTERM_BP_FAT GO:0050877~neurological system process 8 9.411764705882353 0.5257971563490477 GPX1, STX4, SBDS, SLC12A2, RAB14, SNAPIN, TIMP3, TGFB1 77 1210 13528 1.1615756144681766 1.0 0.9987016832152478 99.99931325438129 GOTERM_BP_FAT GO:0050890~cognition 4 4.705882352941177 0.8930785995291313 GPX1, SBDS, SLC12A2, TIMP3 77 909 13528 0.7731058820167731 1.0 0.9999997987767979 99.99999999999997 GOTERM_BP_FAT GO:0007600~sensory perception 3 3.5294117647058822 0.9469361431282726 GPX1, SLC12A2, TIMP3 77 810 13528 0.6506974506974507 1.0 0.9999999979238405 100.0 Annotation Cluster 22 Enrichment Score: 0.49212195861143376 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0003924~GTPase activity 4 4.705882352941177 0.12631234694891869 GSPT1, RAB14, EIF2S3, EHD1 77 211 12983 3.1964054902443526 0.9999999999999962 0.8745844032383209 82.61821785091279 GOTERM_MF_FAT GO:0005525~GTP binding 4 4.705882352941177 0.3720783840306959 GSPT1, RAB14, EIF2S3, EHD1 77 372 12983 1.8130149420472002 1.0 0.9877573766482993 99.75941919685734 UP_SEQ_FEATURE nucleotide phosphate-binding region:GTP 3 3.5294117647058822 0.37297239586647635 GSPT1, RAB14, EIF2S3 85 295 19113 2.286699900299103 1.0 0.9999999999999876 99.82786849354808 GOTERM_MF_FAT GO:0032561~guanyl ribonucleotide binding 4 4.705882352941177 0.3880596714207425 GSPT1, RAB14, EIF2S3, EHD1 77 382 12983 1.765553817909839 1.0 0.9866313708378267 99.82774228213854 GOTERM_MF_FAT GO:0019001~guanyl nucleotide binding 4 4.705882352941177 0.3880596714207425 GSPT1, RAB14, EIF2S3, EHD1 77 382 12983 1.765553817909839 1.0 0.9866313708378267 99.82774228213854 SP_PIR_KEYWORDS gtp-binding 3 3.5294117647058822 0.4223906438418822 GSPT1, RAB14, EIF2S3 85 329 19235 2.063472197389594 1.0 0.9798184532295816 99.89227632173842 Annotation Cluster 23 Enrichment Score: 0.4740411710658209 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE metal ion-binding site:Zinc 2 3 3.5294117647058822 0.040010809982869606 ADH5, NT5E, DNAJA2 85 72 19113 9.369117647058824 0.9999991732855279 0.9999991732855279 42.69545731305272 UP_SEQ_FEATURE metal ion-binding site:Zinc 1 3 3.5294117647058822 0.04204464199512751 NT5E, MMP2, DNAJA2 85 74 19113 9.115898251192368 0.9999996005817531 0.999368004551483 44.32892779968692 SP_PIR_KEYWORDS metal-binding 10 11.76470588235294 0.9180553582706709 ATP2B4, ADH5, MME, ACLY, ANTXR2, NT5E, TIMP3, APEX1, MMP2, DNAJA2 85 2972 19235 0.7614203150977753 1.0 0.9999918323656924 99.99999999999703 SP_PIR_KEYWORDS zinc 7 8.235294117647058 0.9271013912586397 HINT1, ADH5, MME, NT5E, TIMP3, MMP2, DNAJA2 85 2189 19235 0.7236449627818236 1.0 0.9999936758488707 99.99999999999932 GOTERM_MF_FAT GO:0008270~zinc ion binding 5 5.88235294117647 0.9997152703179819 ADH5, MME, NT5E, MMP2, DNAJA2 77 2311 12983 0.3647996313509078 1.0 1.0 100.0 GOTERM_MF_FAT GO:0046914~transition metal ion binding 5 5.88235294117647 0.9999828297129243 ADH5, MME, NT5E, MMP2, DNAJA2 77 2785 12983 0.30271165100608544 1.0 1.0 100.0 Annotation Cluster 24 Enrichment Score: 0.4618410410736691 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009628~response to abiotic stimulus 5 5.88235294117647 0.15231088170897258 GPX1, SLC12A2, XRCC6, TIMP3, TGFB1 77 368 13528 2.3870694522868434 1.0 0.9081011829453516 92.81348452599535 GOTERM_BP_FAT GO:0009314~response to radiation 3 3.5294117647058822 0.310044106308887 GPX1, XRCC6, TGFB1 77 200 13528 2.6353246753246755 1.0 0.977957074368832 99.7297469332961 GOTERM_BP_FAT GO:0019725~cellular homeostasis 4 4.705882352941177 0.48919976096830997 GPX1, SLC12A2, APEX1, TGFB1 77 466 13528 1.5080541775820746 1.0 0.9977251504058025 99.99775478646296 GOTERM_BP_FAT GO:0042592~homeostatic process 5 5.88235294117647 0.6151700553826728 GPX1, SLC12A2, XRCC6, APEX1, TGFB1 77 751 13528 1.1696958168329672 1.0 0.9995872688496251 99.99997535934114 Annotation Cluster 25 Enrichment Score: 0.4521040711315928 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0008092~cytoskeletal protein binding 7 8.235294117647058 0.07444068439508265 STX4, SBDS, PFN2, EZR, TNNT1, MYPN, NEXN 77 504 12983 2.341810966810967 0.9999999945619018 0.7686523154446752 63.299942462193556 GOTERM_CC_FAT GO:0015629~actin cytoskeleton 4 4.705882352941177 0.23167845745839638 PFN2, EZR, TNNT1, MYBPH 80 269 12782 2.375836431226766 1.0 0.6902354719244426 96.4102467758179 SP_PIR_KEYWORDS actin-binding 3 3.5294117647058822 0.29338435963927145 PFN2, MYPN, NEXN 85 247 19235 2.7485115503691353 1.0 0.9449182200030064 98.6747147699716 GOTERM_MF_FAT GO:0003779~actin binding 4 4.705882352941177 0.2981054583567926 PFN2, EZR, MYPN, NEXN 77 326 12983 2.068839136323799 1.0 0.9734364192525707 98.98142591384772 GOTERM_CC_FAT GO:0005815~microtubule organizing center 3 3.5294117647058822 0.46566053117617684 EZR, TOM1, APEX1 80 253 12782 1.8945652173913041 1.0 0.9155352330536949 99.96336528613415 GOTERM_CC_FAT GO:0005856~cytoskeleton 10 11.76470588235294 0.48612047032172967 SBDS, PFN2, CTTN, EZR, TNNT1, HINT1, MYBPH, TOM1, NEXN, APEX1 80 1381 12782 1.1569514844315714 1.0 0.9239802893680211 99.97762121192481 SP_PIR_KEYWORDS cytoskeleton 4 4.705882352941177 0.5286859833284832 PFN2, CTTN, EZR, NEXN 85 636 19235 1.4232334443211248 1.0 0.990523851010546 99.9914362071106 GOTERM_CC_FAT GO:0015630~microtubule cytoskeleton 4 4.705882352941177 0.6656737054053428 SBDS, EZR, TOM1, APEX1 80 549 12782 1.1641165755919856 1.0 0.9704861912564124 99.99990159830344 GOTERM_CC_FAT GO:0044430~cytoskeletal part 6 7.0588235294117645 0.7100483560287711 SBDS, EZR, TNNT1, MYBPH, TOM1, APEX1 80 952 12782 1.0069852941176471 1.0 0.9801681000730459 99.99998369745497 Annotation Cluster 26 Enrichment Score: 0.39888877701857994 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS nucleotide-binding 13 15.294117647058824 0.062002166072563925 ABCF1, ATP2B4, GSPT1, UBA2, XRCC6, GARS, RAB14, EIF2S3, ACLY, ASNS, FARSA, EHD1, NT5E 85 1686 19235 1.7448538134114857 0.9999954000573921 0.6114539543976458 54.92779688176314 SP_PIR_KEYWORDS ligase 4 4.705882352941177 0.14869327541688715 UBA2, GARS, ASNS, FARSA 85 305 19235 2.9677917068466733 0.9999999999999623 0.8376756093918089 86.52399161443465 GOTERM_MF_FAT GO:0000166~nucleotide binding 18 21.176470588235293 0.15340668469594165 ABCF1, XRCC6, GARS, ADH5, EIF2S3, SSB, ASNS, ACLY, HADHB, HNRNPA3, ATP2B4, EIF3G, GSPT1, UBA2, RAB14, FARSA, EHD1, NT5E 77 2245 12983 1.3518873109073555 1.0 0.8973033970903852 88.44389827798285 SP_PIR_KEYWORDS atp-binding 9 10.588235294117647 0.22149409822608893 ABCF1, ATP2B4, UBA2, XRCC6, GARS, ACLY, ASNS, FARSA, EHD1 85 1326 19235 1.5359329252062817 1.0 0.9096112607444355 95.57212992345654 GOTERM_MF_FAT GO:0032553~ribonucleotide binding 12 14.117647058823529 0.5168673064835732 ABCF1, ATP2B4, GSPT1, UBA2, XRCC6, GARS, RAB14, EIF2S3, ACLY, ASNS, FARSA, EHD1 77 1836 12983 1.1020286902639842 1.0 0.9974334797075207 99.99194368475406 GOTERM_MF_FAT GO:0032555~purine ribonucleotide binding 12 14.117647058823529 0.5168673064835732 ABCF1, ATP2B4, GSPT1, UBA2, XRCC6, GARS, RAB14, EIF2S3, ACLY, ASNS, FARSA, EHD1 77 1836 12983 1.1020286902639842 1.0 0.9974334797075207 99.99194368475406 GOTERM_MF_FAT GO:0017076~purine nucleotide binding 12 14.117647058823529 0.5789994752948504 ABCF1, ATP2B4, GSPT1, UBA2, XRCC6, GARS, RAB14, EIF2S3, ACLY, ASNS, FARSA, EHD1 77 1918 12983 1.0549138036103625 1.0 0.9989564796405026 99.99864649832027 GOTERM_MF_FAT GO:0005524~ATP binding 9 10.588235294117647 0.6462939381544506 ABCF1, ATP2B4, UBA2, XRCC6, GARS, ACLY, ASNS, FARSA, EHD1 77 1477 12983 1.0274160504356848 1.0 0.9991763859065891 99.99985831795306 GOTERM_MF_FAT GO:0032559~adenyl ribonucleotide binding 9 10.588235294117647 0.6616840390127918 ABCF1, ATP2B4, UBA2, XRCC6, GARS, ACLY, ASNS, FARSA, EHD1 77 1497 12983 1.0136897170965307 1.0 0.9991026075366348 99.9999203902451 GOTERM_MF_FAT GO:0030554~adenyl nucleotide binding 9 10.588235294117647 0.7193345111993316 ABCF1, ATP2B4, UBA2, XRCC6, GARS, ACLY, ASNS, FARSA, EHD1 77 1577 12983 0.9622660155317099 1.0 0.9996693670823957 99.99999292641316 GOTERM_MF_FAT GO:0001883~purine nucleoside binding 9 10.588235294117647 0.7353521861617986 ABCF1, ATP2B4, UBA2, XRCC6, GARS, ACLY, ASNS, FARSA, EHD1 77 1601 12983 0.9478410409078741 1.0 0.999656434248301 99.99999669674034 GOTERM_MF_FAT GO:0001882~nucleoside binding 9 10.588235294117647 0.7424910696062405 ABCF1, ATP2B4, UBA2, XRCC6, GARS, ACLY, ASNS, FARSA, EHD1 77 1612 12983 0.9413731429860462 1.0 0.9996460627282018 99.99999768232018 UP_SEQ_FEATURE nucleotide phosphate-binding region:ATP 4 4.705882352941177 0.8015058742033132 UBA2, GARS, ACLY, EHD1 85 962 19113 0.9349639231992174 1.0 1.0 99.99999997343603 Annotation Cluster 27 Enrichment Score: 0.376197677575462 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS hydrolase 11 12.941176470588237 0.13945794636437195 PSMB5, ATP2B4, PSMA5, HINT1, ATP6V1E1, XRCC6, MME, ATP6V1B2, PAFAH1B2, NT5E, MMP2 85 1555 19235 1.6007944013618312 0.9999999999997006 0.8350830920888813 84.5864353126451 SP_PIR_KEYWORDS Protease 4 4.705882352941177 0.35448430084566007 PSMB5, PSMA5, MME, MMP2 85 484 19235 1.8701993193971802 1.0 0.9653195844656077 99.57015490709735 GOTERM_MF_FAT GO:0004175~endopeptidase activity 4 4.705882352941177 0.3768808044506082 PSMB5, PSMA5, MME, MMP2 77 375 12983 1.7985108225108226 1.0 0.9865626155902966 99.78220139015826 GOTERM_MF_FAT GO:0070011~peptidase activity, acting on L-amino acid peptides 4 4.705882352941177 0.6291333965593294 PSMB5, PSMA5, MME, MMP2 77 549 12983 1.2284909989828023 1.0 0.9992358765056353 99.99973822489956 GOTERM_MF_FAT GO:0008233~peptidase activity 4 4.705882352941177 0.6593002887258032 PSMB5, PSMA5, MME, MMP2 77 574 12983 1.1749852934521925 1.0 0.9992221351076056 99.99991280756659 GOTERM_BP_FAT GO:0006508~proteolysis 6 7.0588235294117645 0.7157208004494938 PSMB5, PSMA5, UBA2, PSMD3, MME, MMP2 77 1054 13528 1.000123216442002 1.0 0.9999119324457673 99.99999980232779 Annotation Cluster 28 Enrichment Score: 0.27144195319128717 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0042803~protein homodimerization activity 4 4.705882352941177 0.3109597205824328 LGALS1, ADH5, ASNS, TGFB1 77 334 12983 2.019286103118439 1.0 0.974394871153677 99.19836706941825 GOTERM_BP_FAT GO:0010033~response to organic substance 5 5.88235294117647 0.5824637627117754 ADH5, ASNS, TIMP3, TGFB1, B2M 77 721 13528 1.218365545688708 1.0 0.9994296038717996 99.99990960984421 GOTERM_MF_FAT GO:0046983~protein dimerization activity 4 4.705882352941177 0.6203739176615843 LGALS1, ADH5, ASNS, TGFB1 77 542 12983 1.2443571188958644 1.0 0.9992683716876622 99.99964575761848 GOTERM_MF_FAT GO:0042802~identical protein binding 4 4.705882352941177 0.7304754218722156 LGALS1, ADH5, ASNS, TGFB1 77 640 12983 1.0538149350649353 1.0 0.9996850946740582 99.9999958149525 Annotation Cluster 29 Enrichment Score: 0.2710053288303327 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005759~mitochondrial matrix 3 3.5294117647058822 0.41085788116987587 GARS, ECHS1, HADHB 80 227 12782 2.111563876651982 1.0 0.8904733253076527 99.87433995008975 GOTERM_CC_FAT GO:0031980~mitochondrial lumen 3 3.5294117647058822 0.41085788116987587 GARS, ECHS1, HADHB 80 227 12782 2.111563876651982 1.0 0.8904733253076527 99.87433995008975 GOTERM_CC_FAT GO:0005739~mitochondrion 8 9.411764705882353 0.512778353047988 GPX1, SLC25A6, ATP6V1E1, GARS, ADH5, ECHS1, MYCBP, HADHB 80 1087 12782 1.1758969641214352 1.0 0.9349329695310061 99.98857707208 SP_PIR_KEYWORDS mitochondrion 4 4.705882352941177 0.7100268071675004 SLC25A6, ECHS1, MYCBP, HADHB 85 832 19235 1.087952488687783 1.0 0.9990797556582304 99.99997975691876 GOTERM_CC_FAT GO:0044429~mitochondrial part 4 4.705882352941177 0.7184320237833564 SLC25A6, GARS, ECHS1, HADHB 80 595 12782 1.0741176470588236 1.0 0.9808120589234651 99.99998874376817 Annotation Cluster 30 Enrichment Score: 0.20074750384567214 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0070013~intracellular organelle lumen 12 14.117647058823529 0.5488870325407469 HNRNPA3, SBDS, RPS15, XRCC6, RPL3, GARS, ECHS1, SSB, RPS2, APEX1, TGFB1, HADHB 80 1779 12782 1.0777403035413153 1.0 0.9403858079981086 99.99567878331422 GOTERM_CC_FAT GO:0043233~organelle lumen 12 14.117647058823529 0.5811860498113569 HNRNPA3, SBDS, RPS15, XRCC6, RPL3, GARS, ECHS1, SSB, RPS2, APEX1, TGFB1, HADHB 80 1820 12782 1.0534615384615384 1.0 0.9517637392179225 99.99830841208386 GOTERM_CC_FAT GO:0031974~membrane-enclosed lumen 12 14.117647058823529 0.6087852727763274 HNRNPA3, SBDS, RPS15, XRCC6, RPL3, GARS, ECHS1, SSB, RPS2, APEX1, TGFB1, HADHB 80 1856 12782 1.0330280172413793 1.0 0.9555518607477196 99.99928461260149 GOTERM_CC_FAT GO:0005730~nucleolus 5 5.88235294117647 0.632700346316316 HNRNPA3, SBDS, RPL3, SSB, RPS2 80 698 12782 1.1445200573065903 1.0 0.962023045705607 99.99967737083726 GOTERM_CC_FAT GO:0031981~nuclear lumen 8 9.411764705882353 0.8068673066571684 HNRNPA3, SBDS, RPS15, XRCC6, RPL3, SSB, RPS2, APEX1 80 1450 12782 0.8815172413793104 1.0 0.9936165304970392 99.99999990351627 Annotation Cluster 31 Enrichment Score: 0.18596619248440333 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0034622~cellular macromolecular complex assembly 3 3.5294117647058822 0.5365917255359696 RPS15, RPL24, TGFB1 77 318 13528 1.6574369027199216 1.0 0.9988167511022371 99.99952417256168 GOTERM_BP_FAT GO:0034621~cellular macromolecular complex subunit organization 3 3.5294117647058822 0.5998966263924657 RPS15, RPL24, TGFB1 77 357 13528 1.4763723671286695 1.0 0.9994950224602508 99.99995418673346 GOTERM_BP_FAT GO:0065003~macromolecular complex assembly 4 4.705882352941177 0.7286715254808155 STX4, RPS15, RPL24, TGFB1 77 665 13528 1.0567717996289425 1.0 0.9999288623222224 99.99999990596584 GOTERM_BP_FAT GO:0043933~macromolecular complex subunit organization 4 4.705882352941177 0.7689233338283844 STX4, RPS15, RPL24, TGFB1 77 710 13528 0.9897933052862631 1.0 0.9999686866002245 99.99999999272126 Annotation Cluster 32 Enrichment Score: 0.16487848007530728 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS cell adhesion 3 3.5294117647058822 0.5530621555379953 TNXB, MYBPH, NID2 85 422 19235 1.608725954836911 1.0 0.992029551121465 99.99557894798473 GOTERM_BP_FAT GO:0007155~cell adhesion 4 4.705882352941177 0.7604125351302304 EZR, TNXB, MYBPH, NID2 77 700 13528 1.0039332096474956 1.0 0.9999670476866274 99.99999998704764 GOTERM_BP_FAT GO:0022610~biological adhesion 4 4.705882352941177 0.7612746186111634 EZR, TNXB, MYBPH, NID2 77 701 13528 1.0025010652685402 1.0 0.9999655859675821 99.99999998777064 Annotation Cluster 33 Enrichment Score: 0.144345311139982 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0016563~transcription activator activity 4 4.705882352941177 0.43226500144446467 XRCC6, MYCBP, APEX1, TGFB1 77 410 12983 1.6449794108330695 1.0 0.9917874686220743 99.93480377784512 GOTERM_BP_FAT GO:0042592~homeostatic process 5 5.88235294117647 0.6151700553826728 GPX1, SLC12A2, XRCC6, APEX1, TGFB1 77 751 13528 1.1696958168329672 1.0 0.9995872688496251 99.99997535934114 GOTERM_MF_FAT GO:0030528~transcription regulator activity 4 4.705882352941177 0.9951310116099896 XRCC6, MYCBP, APEX1, TGFB1 77 1512 12983 0.44605923177351753 1.0 0.9999999999995707 100.0 GOTERM_BP_FAT GO:0045449~regulation of transcription 4 4.705882352941177 0.9999844200749598 RPL6, XRCC6, MYCBP, TGFB1 77 2601 13528 0.27018579267714216 1.0 1.0 100.0 Annotation Cluster 34 Enrichment Score: 0.1379236517253581 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007276~gamete generation 3 3.5294117647058822 0.655235031725109 MYCBP, PAFAH1B2, TGFB1 77 395 13528 1.334341607759329 1.0 0.9997683694793341 99.99999572565675 GOTERM_BP_FAT GO:0019953~sexual reproduction 3 3.5294117647058822 0.7335277529712871 MYCBP, PAFAH1B2, TGFB1 77 458 13528 1.1507968014518233 1.0 0.9999334299758446 99.9999999294806 GOTERM_BP_FAT GO:0032504~multicellular organism reproduction 3 3.5294117647058822 0.7642683365216546 MYCBP, PAFAH1B2, TGFB1 77 487 13528 1.0822688605029467 1.0 0.9999663153750559 99.99999998999829 GOTERM_BP_FAT GO:0048609~reproductive process in a multicellular organism 3 3.5294117647058822 0.7642683365216546 MYCBP, PAFAH1B2, TGFB1 77 487 13528 1.0822688605029467 1.0 0.9999663153750559 99.99999998999829 Annotation Cluster 35 Enrichment Score: 0.047708110635886314 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0005509~calcium ion binding 6 7.0588235294117645 0.6322401454399758 COPA, FBLN1, ATP2B4, NID2, EHD1, MMP2 77 919 12983 1.1008295295564066 1.0 0.9991158259083985 99.9997652597739 SP_PIR_KEYWORDS metal-binding 10 11.76470588235294 0.9180553582706709 ATP2B4, ADH5, MME, ACLY, ANTXR2, NT5E, TIMP3, APEX1, MMP2, DNAJA2 85 2972 19235 0.7614203150977753 1.0 0.9999918323656924 99.99999999999703 GOTERM_MF_FAT GO:0043169~cation binding 15 17.647058823529413 0.9976526699207537 COPA, SLC12A2, ADH5, MME, ACLY, NID2, MMP2, FBLN1, ATP2B4, GBE1, ANTXR2, EHD1, APEX1, NT5E, DNAJA2 77 4179 12983 0.6052059928585414 1.0 0.9999999999999827 100.0 GOTERM_MF_FAT GO:0043167~ion binding 15 17.647058823529413 0.9982052757995645 COPA, SLC12A2, ADH5, MME, ACLY, NID2, MMP2, FBLN1, ATP2B4, GBE1, ANTXR2, EHD1, APEX1, NT5E, DNAJA2 77 4241 12983 0.5963583692892819 1.0 0.9999999999999916 100.0 GOTERM_MF_FAT GO:0046872~metal ion binding 14 16.470588235294116 0.998870709427323 COPA, FBLN1, ATP2B4, SLC12A2, ADH5, MME, ACLY, ANTXR2, NID2, EHD1, NT5E, APEX1, MMP2, DNAJA2 77 4140 12983 0.5701800614844094 1.0 0.9999999999999984 100.0 Annotation Cluster 36 Enrichment Score: 0.006617850767032881 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS membrane 23 27.058823529411764 0.9149895250242176 COPA, STX4, SCAMP3, STX7, PLXNA1, SLC12A2, SLC25A6, MME, SNAPIN, ATP6V1B2, NID2, MMP2, ATP2B4, EZR, AP2A1, COPB1, RAB14, TOM1, ANTXR2, PTGFRN, EHD1, NT5E, DNAJA2 85 6256 19235 0.8319636678200691 1.0 0.9999927311162223 99.99999999999531 UP_SEQ_FEATURE topological domain:Cytoplasmic 9 10.588235294117647 0.9875919202895997 STX4, SCAMP3, ATP2B4, STX7, SLC12A2, PLXNA1, MME, ANTXR2, PTGFRN 85 3374 19113 0.5998012483001499 1.0 1.0 100.0 UP_SEQ_FEATURE topological domain:Extracellular 6 7.0588235294117645 0.9950101590525154 STX4, ATP2B4, PLXNA1, MME, ANTXR2, PTGFRN 85 2719 19113 0.4961945351881098 1.0 1.0 100.0 UP_SEQ_FEATURE transmembrane region 10 11.76470588235294 0.9998219714883883 STX4, SCAMP3, ATP2B4, STX7, SLC12A2, PLXNA1, SLC25A6, MME, ANTXR2, PTGFRN 85 4911 19113 0.45786769197599625 1.0 1.0 100.0 SP_PIR_KEYWORDS transmembrane 10 11.76470588235294 0.9998416324931375 STX4, SCAMP3, ATP2B4, STX7, SLC12A2, PLXNA1, SLC25A6, MME, ANTXR2, PTGFRN 85 4973 19235 0.4550454808909286 1.0 0.9999999999999993 100.0 GOTERM_CC_FAT GO:0031224~intrinsic to membrane 13 15.294117647058824 0.999999973473785 STX4, SCAMP3, ATP2B4, STX7, SLC12A2, PLXNA1, SLC25A6, MME, ANTXR2, ATP6V1B2, PTGFRN, NT5E, DNAJA2 80 5485 12782 0.37868277119416593 1.0 1.0 100.0 GOTERM_CC_FAT GO:0016021~integral to membrane 11 12.941176470588237 0.9999999955753683 STX4, SCAMP3, ATP2B4, STX7, SLC12A2, PLXNA1, SLC25A6, MME, ANTXR2, ATP6V1B2, PTGFRN 80 5297 12782 0.3317962997923353 1.0 1.0 100.0 Annotation Cluster 37 Enrichment Score: 7.486225162373242E-5 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006355~regulation of transcription, DNA-dependent 3 3.5294117647058822 0.9997197841533959 RPL6, XRCC6, TGFB1 77 1773 13528 0.29727294701913987 1.0 1.0 100.0 GOTERM_BP_FAT GO:0051252~regulation of RNA metabolic process 3 3.5294117647058822 0.9997787295308803 RPL6, XRCC6, TGFB1 77 1813 13528 0.2907142498979234 1.0 1.0 100.0 GOTERM_BP_FAT GO:0045449~regulation of transcription 4 4.705882352941177 0.9999844200749598 RPL6, XRCC6, MYCBP, TGFB1 77 2601 13528 0.27018579267714216 1.0 1.0 100.0