>XP_002609562.1 hypothetical protein BRAFLDRAFT_129882 [Branchiostoma floridae] -----------------------------------------------------------MS---------------------------------------------RQTISGKP---------------------------NRHTPTSSAT------------------------------STQ----------------------------DLAGLFECPVCFDYVLPPILQCQSGHLVCSSCRPKL--SCCPTCRGPL-GNIRNLAMEKVASTVMFPCKYASAGCPVTLLHTEKPDHEEICDFRPYSCPCPGSSCKWQGSLDAVMPHLTHAHKSITTLQ----GEDIVF---LATDINLPGAVDWVMMQSCFGHNFMLVLEKQEKYD---GHQQFFAIVQLIGTRKQAENFAYRLEL--NGHRRRLTWEATPRSIHEGVASAISSSDCLVFDTNIARLFADNGNLGINVTISTC------------------- >XP_797311.2 PREDICTED: E3 ubiquitin-protein ligase SIAH1 isoform X2 [Strongylocentrotus purpuratus] -----------------------------------------------------------MS---------------------------------------------RPAANGKA---------------------------RSHTPTTN----------------------------------Q----------------------------DLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL--NCCPTCRGPL-GSIRNLAMEKVAQTVMFPCRYASSGCVATMSYNEKQDHEETCEFRPYSCPCPGASCKWQGSLDQVMPHLTHAHKSITTLQ----GEDIVF---LATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYD---GLQQFFAIVQLIGSRKQAENFAYRLEL--NGHRRRLSWEATPRSIHEGVQAAIMNSDCLVFDSSIAQLFAENGNLGINVTISMC------------------- >NP_476725.1 seven in absentia, isoform A [Drosophila melanogaster] -----------------------------------------------------------MSNKI--------------------------------------NPKRREPTAAAAGAGATGVATNTSTST---GSSSAGNTSSANTSSSSSS------------------SLSSAGGG-DAGMSA----------------------------DLTSLFECPVCFDYVLPPILQCSSGHLVCVSCRSKL--TCCPTCRGPL-ANIRNLAMEKVASNVKFPCKHSGYGCTASLVYTEKTEHEETCECRPYLCPCPGASCKWQGPLDLVMQHLMMSHKSITTLQ----GEDIVF---LATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYD---GHQQFFAIVQLIGSRKEAENFVYRLEL--NGNRRRLTWEAMPRSIHEGVASAIHNSDCLVFDTSIAQLFADNGNLGINVTISLV------------------- >XP_001688791.1 AGAP006127-PA [Anopheles gambiae str. PEST] -----MLT------VTAGTATHPSH--TETAEQT----AETTAATTTTTTTT-TTMSNKLNN-----------------------------------------PKRREVTGSSS---------------------------SNSSISSVGA--------------------GDSG------ISA----------------------------DLASLFECPVCFDYVLPPILQCQSGHLVCTSCRSKL--TCCPTCRGSL-GNIRNLAMEKVASNVKFPCKHSNHGCTVSLVYTEKAEHEEACEFRPYLCPCPGASCKWQGSLDYVMPHLMMSHKSITTLQ----GEDIVF---LATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYD---GHQQFYAIVQLIGSRKEAENFAYRLEL--NGNRRRLTWEAMPRSIHEGVASAILNSDCLVFDTSIAQLFADNGNLGINVTISVV------------------- >XP_394284.2 PREDICTED: E3 ubiquitin-protein ligase Siah1 [Apis mellifera] ---MSQLS------ISTG---------------------------------------------------------------------------------------KRGRSVASS---------------------------SAPTVSSLS-------------------------------SST----------------------------DLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL--NCCPTCRGPL-GNIRNLAMEKVAGNVMFPCKYSTSGCTVSLVHTEKADHEDACEFRPYSCPCPGASCKWQGSLEQVMPHLVMSHKSITTLQ----GEDIVF---LATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYD---GHQQFFAIVQLIGSRKQAENFAYRLEL--NGHKRRLTWEAMPRSIHEGVSSAILNSDCLVFDTSIAQLFADNGNLGINVTISMA------------------- >XP_008186354.1 PREDICTED: E3 ubiquitin-protein ligase Siah1 [Acyrthosiphon pisum] MAENTSIS------NNSGIVEFNHH--LVTDQETRMSGSGGSNSGGTSIGNP-TASVNTVSVLLPSG-----------------------------------GGTKRRSAVGNN---------------------------SSHNGGSASN--------------------SAS-------ISA----------------------------DLASLFECPVCFDYVLPPILQCQSGHLVCSTCRPKL--NCCPTCRGPL-GNIRNLAMEKVASTVMFPCKYSSSGCPVSLLHSEKVEHEELCECRPYTCPCPGASCKWQGGLEQVMEHLMVAHKSITTLQ----GEDIVF---LATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYE---GHQQFFAIVQLIGSRKQCENFAYRLEL--NGHRRRLAWEATPRSIHEGVSTAILNSDCLVFDTSTAQLFADNGNLGINVTISTNV------------------ >NP_500409.1 E3 ubiquitin-protein ligase siah-1 [Caenorhabditis elegans] -MSN----------RNGGGGGGDYQDVIESLRRTQLIFEEDDNNSSDSAPQANHLSRHQTSNSLVEDM------VNHSNGNPPPVPPGITQQQCQIGLTP------RMSASPPSA-----VSTISGTAVLGKTMARVQSNPPGSIPHNTTTTAQGIQSVAPHI------PIGGGGAT--DDSSA----------------------------EILSVFECPVCLEYMLPPYMQCSSGHLVCSNCRPKL--QCCPTCRGPT-PSVRNLGLEKIANTVRFPCKFSTSGCPLNFHHADKTEHEELCEFRPYCCPCPGASCKWQGGLSDVMEHLKKIHKSITTLQ----GEDIVF---LATDINLPGAVDWVMMQSCFDYNFMLVLEKQEKYDPAQPTQMFYAVVQLIGSKKEADNFVYRLEL--SASRRRMSWEATPRSIHEGVVVAIQQSDCLAFDSNAAQLFAENGNLGINVTISRIDTPQRRHPNELENSDLEYD >XP_013306181.1 seven in absentia protein [Necator americanus] MSSNNHSQVPSVAVSSSGSASATA-----------LCGPNGSNSSNT--AGERSDRSGSRSGSPPSQ-------FMGPTAPNHGVA------------APHQKNLARVQATAPPV--------------------------VTCSPSSLSTQS-----VAPQIA-----TIGASEHT-DSSAEPYKEETTPRLLPETELDVTSPLLVPIEQQGVLSVFECPVCLEYMLPPYLQCQAGHLVCGNCRPKL--QCCPTCRGPT-PSVRNLGLEKIANTVRFPCKFASSGCPLFFYHFDKVEHEEACECRPYSCPCPGAACKWQGALNDVMDHLKKVHKSITTLQ----GEDIVF---LATDINLPGAVDWVMMQSCFGYNFMLVLEKQEKFD--HGQQVFYAVVQLIGAKKEADNFMYRLEL--STHRRRLCWEATPRSIHEGVAHAIQLSDCLAFDTPTAQLFAENGNLGINVTISMV------------------- >XP_001898781.1 Ubiquitin ligase sia-1 [Brugia malayi] -MSNEFKQ---------GSIAT------------------------------------------PAA-------VNGQNNPTQGVA------------TPQQKTVGRVQGSTPSG--------------------------SVSNP--VTTQS-----VAPQFA------VSTPHNV-THNANP----------------------------EVLSVFECPVCMDYMMPPYLQCQSGHLVCGNCRPKL--TCCPTCRGPV-PSVRNLVLEKIANTVMFPCKFSGSGCPLTFSHVEKVEHEELCEFRPYCCPCPGASCKWQGSLSEVMGHLMKVHKSITTLQ----GEDIVF---LATDINLPGAVDWVMMQSCFGYHFMLVLEKQEKFQ--DGNQMFYAVVQLIGAKKESENFMYRLEL--ATHRRRFSWEASPRSIHEGVAHAISLSDCMAFDSQTAQLFAENGNLGINVTISMV------------------- >XP_003379392.1 E3 ubiquitin-protein ligase Siah1 [Trichinella spiralis] ---------------MAGV------------------------------------NTTQISTDV------------------------------------------QPTAPAPA-------------------------SSGTAVPTQLST--------------------SSSAHVPQNSCTA----------------------------EVLSVFECPVCLDYMLPPYLQCQSGHLVCGNCRPKL--TCCPTCRGPV-PSVRNLVMEKIANSVLFPCKFSSNGCPAAMLYQEKVEHEEACEFRPYSCPCPGASCKWQGNLDAVMPHLVKIHKSITTLQGINLGEDIVF---LATDINLPGSVDWVMMQSCFGYHFMLVLEKQEKCD---GHQMFYAVVQLIGSRQHAENFLYRLEL--SSVRRRLCWEATPRSIHEGVANAISQSDCLAFDTNTAQLFADSGNLGINVTITMVPPYIMNN------------ >XP_014779248.1 PREDICTED: E3 ubiquitin-protein ligase SIAH1-like [Octopus bimaculoides] -----------------------------------------------------------MS--------------------------------------------RQPSNSGKA------------------------RGHSQQVPVQESTL---MMNIQTHKSERDCRGLKSST-----TSNN----------------------------DLATLFECPVCFDYALPPIMQCQSGHIVCHSCRQKL--SMCPTCRGPL-GNIRNLAMEKVAMTVLFPCKYSTNGCLVTLLHTEKSEHEETCECRPYCCPCPGASCKWQGSLEQVMSHLVQSHKSITTLQ----GEDIVF---LATDINLPGAVDWVMMQSCFGHNFMLVLEKQEKID---GLQMFYAIVQLIGTRKQAENFAYRLEL--SGHRRRLTWEATPRSIHDGVQSAILSSDCLVFDTNIAQLFADHGNLGINVTISTC------------------- >XP_011434753.1 PREDICTED: E3 ubiquitin-protein ligase Siah1 [Crassostrea gigas] ---------------------------------------------------------MSLS--------------------------------------------RQPSSSGKQP-------------------RQIHNGGSSNVTTTQSV-------------------LAAAG-----SSNS----------------------------DLASLFECPVCFDYALPPITQCQSGHIVCQPCKQKL--NICPTCRGPL-GNIRNLAMEKVATTVMFPCKYSSSGCPVTLLHTDKQEHEETCEYRPYCCPCPGASCKWQGSLEQVMGHLMQQHKSITTLQ----GEDIVF---LATDINLPGAVDWVMMQSCFGHNFMLVLEKQEKLE---GQQMFYAIVQLIGTRKQAENFAYRLEL--NGHRRRLSWEATPRSIHDGVQSAIVASDCLVFDTNIAQLFADHGNLGINVTISMC------------------- >XP_009028819.1 hypothetical protein HELRODRAFT_69385, partial [Helobdella robusta] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSSG-----NSSN----------------------------DLASLFECPVCFDYALPPIMQCQSGHIVCSHCRPKL--QFCPTCRGAL-GNIRNLAMEKVASQVLFPCRYMSNGCEASLPHTDKANHEDGCEFRPYNCPCPGASCKWQGSLEQVMPHLLQQHKSITTLQ----GEDIVF---LATDINLPGAVDWVMMQTCFGHHFMLVLEKQEKSE---GNQLFYTIVQLIGTRKQAESFAYRLEL--NGQKRRLTWEATPRSIHDGVQSAINSSDCLVFDTNVARLFADNGNLSINVTINTC------------------- >XP_018646300.1 ubiquitin ligase sina (ec 6.3.2.-) (seven in absentia homolog)(smsina) [Schistosoma mansoni] -MNNSITE------VNMSV------------------PSRATNSNNTILSEERTCHRSQMASSDAVGRTMALLPINHNHALHHGIK-----------LMPHINMPHREVGATTP------LVTNSGTA----------STCSMSLPGSMSSASDTVCNILPH---------NTSD-----SSSI----------------------------DLASLFECPVCMDYALPPIMQCQSGHIVCASCRSKL--SSCPTCRGNL-DNIRNLAMEKLASSVLFPCKYSTSGCPETFHYTSKSEHEAACEYRPYDCPCPGASCKWLGELEQVMPHLVHHHKSITTLQ----GEDIVF---LATDISLPGAVDWVMMQSCFGHSFMLVLEKQERVP---D-QIFFALVQLIGTRKQADQFVYRLEL--NGHRRRLTWEACPRSIHDGVQSAIAVSDCLVFDSNTAHSFAENGNLGINVTISQVSPSIS-------------- >XP_001637064.1 predicted protein, partial [Nematostella vectensis] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNA----------------------------DLTSIFECPVCFDYVLPPILQCSSGHLVCSNCRPKL--TCCPTCRGPL-GSIRNLAMEKVANTVSFPCKYANSGCEVNLPHTEKAEHEESCEFRPYSCPCPGASCKWQGSLDAVMPHLMHTHKSITTLQ----GEDIVF---LATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYE---GHQQFYAIVQLIGTRKQAESFIYRLEL--NGNRRRLAWEATPRSIHEGIASAILNSDCLVFDANIAHLFADNGNLGINVTISMVS------------------ >XP_020623250.1 E3 ubiquitin-protein ligase Siah1-like [Orbicella faveolata] -----------------------------------------------------------MN---------------------------------------------RQPSSSQP---------------------------SQKPPRMNAN--------------------QPGG-----PTNA----------------------------DLASIFECPVCFDYVLPPILQCSSGHLVCSNCRPKL--TCCPTCRGPL-GSIRNLAMEKVANTVSFPCKYASAGCEVNLPHTEKPEHEESCEFRPYSCPCPGASCKWQGSLDSVMPHLMHAHKSITTLQ----GEDIVF---LATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKIE---GLQQFYAIVQLIGTRKQAENFVYRLEL--NGNRRRLAWEATPRSIHEGIASAILNSDCLVFDTNIAHLFADNGNLGINVTISMVS------------------ >XP_015766642.1 PREDICTED: E3 ubiquitin-protein ligase Siah1-like [Acropora digitifera] -----MLT-------------------------------RGRYLSKNNVGPS-MNFMCDMN---------------------------------------------RQ-STSQS---------------------------SQKPPRMNGT--------------------QQGG-----PTNA----------------------------DLASIFECPVCFDYVLPPIYQCSSGHLVCSNCRPKL--SCCPTCRGPL-AGIRNLAMEKVANTVSFPCKYASAGCEVNLPHTEKTEHEDFCEFRPYSCPCPGASCKWQGSLDSVMPHLMHAHKSITTLQ----GEDIVF---LATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKIE---GLQQFYAIVQLIGTRKQAENFVYRLEL--NGNRRRLAWEATPRSIHEGIASAILNSDCLVFDTNIAHLFADNGNLGINVTISMVS------------------ >XP_002162099.1 PREDICTED: E3 ubiquitin-protein ligase SIAH1-like [Hydra vulgaris] --------------------------------------------------------MSKMSNLM------------------------------------------RPVGTASP---------------------------NAIKGDVPMN--------------------IVSATM-NISSNP----------------------------DLASLFECPVCFDYVLPPIFQCSSGHLLCSNCRPKL--TICPSCRGPL-GSIRNLAMEKVANTVLFPCRYSSSGCNVTLPHTAKIEHEDSCECRPYVCPCPGASCKWSGTLDGVMPHLMVSHKSITTLQ----GEDIVF---LATDINLPGAVDWVMMQSCFGQHFMLVLEKQEKFE---GHQQFFAVVQLIGSRKQAENFAYRLEL--NGQRRRLAWEATPRSIHDGISAAISNSDCLVFDTSIAQLFADNGNLGINVTISLC------------------- >XP_019850617.1 PREDICTED: E3 ubiquitin-protein ligase Siah1-like [Amphimedon queenslandica] -----------------------------------------------------------MTHLP----------------------------------YP---------------------------------------------------------------------TIGAGA-----SDSS---------------------------RDLASLFECPVCFDYVLPPIHQCDSGHLVCSNCQPKLATQICPACRGPL-SGVRNLAMDKVAETVLFPCKYANSGCSLRFLHNEKRKHEETCEFRPYACPCPGTTCRWQGSLDEVLDHLLNAHKTITTLN----GEDIVF---LATDINLPGAVDWVMMQCCFEHHFMLVLEKQERHE---GHQQFFAVVQIIGTEKQAEQFRYKLELVDSRHGRKLAWEAKPRSIHDGISQVISGNDCLIFEPSMAQHFGENGNLAINVTIGRVCY----------------- >XP_002108034.1 hypothetical protein TRIADDRAFT_19965 [Trichoplax adhaerens] -----------------------------------------------------------MD--------------------------------------------ERSDAGLNE-----------------------QTATDSHQNDEDSNYK----------------QIKRKH---EDNQSG---------------DQFS---------SIINLFECPVCYDYVLPPIKQCTRGHLICEKCRLKI--LKCPVCNETFETDVRNLQMEKLARTLVFPCKFRQSGCQLCFSPDERKIHEDSCPFRIYSCPFP-ITCRWQGSLDSVVSHIVNSHKTVPMQD----GEDVVFSFVITSEVTV-----WAMIQKCHDQHFLVLVRKIEMSH---YIYQLYALVQVIAPKSIARNFAYVLTL--KDEQRRLALESSPISINDCIDDAIAVRDCLSVDFVTAKSFSQDGNIRLLVAIKAI-------------------